The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Elastic fibers are essential constituents of the extracellular matrix of higher vertebrates and
endow several tissues and organs including lungs, skin and blood vessels with elasticity …

Elastic fibers are extracellular components of higher vertebrates and confer elasticity and
resilience to numerous tissues and organs such as large blood vessels, lungs, and skin …

Elastic fibres are insoluble components of the extracellular matrix of dynamic connective
tissues such as skin, arteries, lungs and ligaments. They are laid down during development …

The coacervation of tropoelastin represents the first major stage of elastic fiber assembly.
The process has been modeled in vitro by numerous studies, initially with mixtures of …

The eukaryotic V-type adenosine triphosphatase (V-ATPase) is a multi-subunit membrane
protein complex that is evolutionarily related to F-type adenosine triphosphate (ATP) …

Cutis laxa is a rare disorder of elastic tissue resulting in loose, redundant, hypoelastic skin.
Both acquired and inherited forms exist, some of which have significant systemic …

Exocytic and endocytic compartments each have their own unique luminal ion and pH
environment that is important for their normal functioning. A failure to maintain this …

Congenital disorders of glycosylation comprise most of the nearly 70 genetic disorders
known to be caused by impaired synthesis of glycoconjugates. The effects are expressed in …

Autosomal recessive cutis laxa (ARCL) describes a group of syndromal disorders that are
often associated with a progeroid appearance, lax and wrinkled skin, osteopenia and mental …