Caffeine and Purine Derivatives: A Comprehensive Review on the Chemistry, Biosynthetic Pathways, Synthesis‐Related Reactions, Biomedical Prospectives and …
Caffeine and purine derivatives represent interesting chemical moieties, which show various
biological activities. Caffeine is an alkaloid that belongs to the family of methylxanthine …
biological activities. Caffeine is an alkaloid that belongs to the family of methylxanthine …
Targeting cancer through recently developed purine clubbed heterocyclic scaffolds: An overview
A Chaurasiya, C Sahu, SK Wahan… - Journal of Molecular …, 2023 - Elsevier
Cancer is the world's major health issue, scavenging lives of millions throughout the world. A
number of anticancer drugs have figured prominently in the diagnosis and treatment of …
number of anticancer drugs have figured prominently in the diagnosis and treatment of …
From breast cancer to antimicrobial: combating extremely resistant Gram-negative “superbugs” using novel combinations of polymyxin B with selective estrogen …
MH Hussein, EK Schneider, AG Elliott… - Microbial Drug …, 2017 - liebertpub.com
Novel therapeutic approaches are urgently needed to combat nosocomial infections caused
by extremely drug-resistant (XDR)“superbugs.” This study aimed to investigate the …
by extremely drug-resistant (XDR)“superbugs.” This study aimed to investigate the …
Synthesis of some novel 8-(4-Alkylpiperazinyl) caffeine derivatives as potent anti-Leishmania agents
In this paper, the synthesis, characterization and the leishmanicidal assessments of novel 8-
(4-alkylpiperazinyl) caffeine derivatives have been described. These compounds are new …
(4-alkylpiperazinyl) caffeine derivatives have been described. These compounds are new …
Design, synthesis, anticancer and in silico assessment of 8-piperazinyl caffeinyl-triazolylmethyl hybrid conjugates
In this paper, we have assessed the design, synthesis, characterization, anticancer
properties, toxicity, and in silico study of 8-piperazinyl caffeinyl-triazolylmethyl derivatives as …
properties, toxicity, and in silico study of 8-piperazinyl caffeinyl-triazolylmethyl derivatives as …
Lipidomic Analysis of the Outer Membrane Vesicles from Paired Polymyxin-Susceptible and -Resistant Klebsiella pneumoniae Clinical Isolates
Gram-negative bacteria produce outer membrane vesicles (OMVs) as delivery vehicles for
nefarious bacterial cargo such as virulence factors, which are antibiotic resistance …
nefarious bacterial cargo such as virulence factors, which are antibiotic resistance …
Synthesis of novel proxyphylline derivatives with dual Anti-Candida albicans and anticancer activity
P Borowiecki, P Wińska, M Bretner, M Gizińska… - European Journal of …, 2018 - Elsevier
Three out of 16 newly synthesized 1, 3-dimethylxanthine derivatives (proxyphylline
analogues) exhibited consistencies between antifungal and anticancer properties …
analogues) exhibited consistencies between antifungal and anticancer properties …
Thiosemicarbazide binds with the dicopper center in the competitive inhibition of mushroom tyrosinase enzyme: Synthesis and molecular modeling of theophylline …
Theophylline is long known for its anti-ageing and anti-oxidative properties. Moreover,
Tyrosinase is a crucial enzyme that regulates the melanin synthetic pathway, which is …
Tyrosinase is a crucial enzyme that regulates the melanin synthetic pathway, which is …
Synthesis of some novel amino and thiotetrazole purine derivatives and investigation of their antimicrobial activity and DNA interactions
A series of amino and thiotetrazole purine derivatives introduced with different alkyl groups
in position 9 was synthesized. The structures of the synthesized compounds were …
in position 9 was synthesized. The structures of the synthesized compounds were …
Recent advances in the medicinal chemistry of phenothiazines, new anticancer and antiprotozoal agents
A González-González… - Current Medicinal …, 2021 - ingentaconnect.com
Background: Molecules with a phenothiazine scaffold have been considered versatile
organic structures with a wide variety of biological activities, such as antipsychotic …
organic structures with a wide variety of biological activities, such as antipsychotic …