Spinal cord injury (SCI)-related disabilities are a serious problem in the modern society.
Further, the treatment of SCI is highly challenging and is urgently required in clinical …

Peripheral nerve lesions are frequent occurrences in both human and animal patients,
leading to important physiological and labor complications that affect the quality of life of …

Abstract Background Schwann cells (SCs) play an indispensable role in the repair and
regeneration of injured peripheral nerve. Curcumin can reduce SCs apoptosis, and promote …

Background: Isoflavones are natural compounds belonging to the class of isoflavonoids,
molecules with a chemical structure based on the 3-phenyl chromen-4-one backbone. As a …

Among different types of chronic pain, neuropathic pain (NP), arising from damage to the
nervous system, including peripheral fibers and central neurons, is notoriously difficult to …

Fascicular rearrangement of an injured peripheral nerve requires reconnection of nerve
sprouts from anterior and Büngner bands from distal sides of the lesion, failing to which …

Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in NAD+
biosynthesis via salvage of NAM formed from catabolism of NAD+ by proteins with NADase …

BACKGROUND: Peripheral nerve damage mainly resulted from traumatic or infectious
causes; the main signs of a damaged nerve are the loss of sensory and/or motor functions …

Peripheral nerve injury (PNI) can result from trauma, surgical resection, iatrogenic injury,
and/or local anesthetic toxicity. Damage to peripheral nerves may result in debilitating …

In the central and peripheral nervous systems, myelin is essential for efficient conduction of
action potentials. During development, oligodendrocytes and Schwann cells differentiate …