Improved COVID‐19 outcomes following statin therapy: an updated systematic review and meta‐analysis

A Vahedian-Azimi, SM Mohammadi… - BioMed research …, 2021 - Wiley Online Library
Background. Although vaccine rollout for COVID‐19 has been effective in some countries,
there is still an urgent need to reduce disease transmission and severity. We recently carried …

[HTML][HTML] Improved COVID-19 ICU admission and mortality outcomes following treatment with statins: a systematic review and meta-analysis

A Vahedian-Azimi, SM Mohammadi… - Archives of Medical …, 2021 - ncbi.nlm.nih.gov
Results The final selected studies (n= 24 studies; 32,715 patients) showed significant
reductions in ICU admission (OR= 0.78, 95% CI: 0.58–1.06; n= 10; I 2= 58.5%) and death …

Genetic screens identify host factors for SARS-CoV-2 and common cold coronaviruses

R Wang, CR Simoneau, J Kulsuptrakul, M Bouhaddou… - Cell, 2021 - cell.com
The Coronaviridae are a family of viruses that cause disease in humans ranging from mild
respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host …

SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

DW Sanders, CC Jumper, PJ Ackerman, D Bracha… - Elife, 2021 - elifesciences.org
Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane
fusion events caused by the same machinery that underlies viral entry. These syncytia are …

[HTML][HTML] PoLA/CFPiP/PCS/PSLD/PSD/PSH guidelines on diagnosis and therapy of lipid disorders in Poland 2021

M Banach, P Burchardt, K Chlebus… - Archives of Medical …, 2021 - ncbi.nlm.nih.gov
Moreover, over the last few years the approach to treatment of patients with a high
cardiovascular risk has totally changed from treatment aimed at a specific risk factor (ie …

The role of high cholesterol in age-related COVID19 lethality

H Wang, Z Yuan, MA Pavel, SM Jablonski… - BioRxiv, 2021 - pmc.ncbi.nlm.nih.gov
Coronavirus disease 2019 (COVID19) is a respiratory infection caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) originating in Wuhan, China in 2019 …

Molecular simulations suggest vitamins, retinoids and steroids as ligands of the free fatty acid pocket of the SARS‐CoV‐2 Spike protein

DK Shoemark, CK Colenso, C Toelzer… - Angewandte …, 2021 - Wiley Online Library
We investigate binding of linoleate and other potential ligands to the recently discovered
fatty acid binding site in the SARS‐CoV‐2 spike protein, using docking and molecular …

Time to recovery from COVID-19 and its predictors among patients admitted to treatment center of Wollega University Referral Hospital (WURH), Western Ethiopia …

T Tolossa, B Wakuma, D Seyoum Gebre… - Plos one, 2021 - journals.plos.org
Introduction Despite its alarming spread throughout the world, no effective drug and vaccine
is discovered for COVID-19 so far. According to WHO, the recovery time from COVID-19 was …

[HTML][HTML] Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients

C Diaz-Arocutipa, B Melgar-Talavera… - International Journal of …, 2021 - Elsevier
Objectives There is conflicting evidence about the efficacy of statin use in regard to clinical
outcomes in patients with coronavirus disease 2019 (COVID-19). A systematic review and …

Simvastatin downregulates the SARS-CoV-2-induced inflammatory response and impairs viral infection through disruption of lipid rafts

L Teixeira, JR Temerozo, FS Pereira-Dutra… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is currently a worldwide emergency caused by
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In observational clinical …