Improved COVID‐19 outcomes following statin therapy: an updated systematic review and meta‐analysis
A Vahedian-Azimi, SM Mohammadi… - BioMed research …, 2021 - Wiley Online Library
Background. Although vaccine rollout for COVID‐19 has been effective in some countries,
there is still an urgent need to reduce disease transmission and severity. We recently carried …
there is still an urgent need to reduce disease transmission and severity. We recently carried …
[HTML][HTML] Improved COVID-19 ICU admission and mortality outcomes following treatment with statins: a systematic review and meta-analysis
A Vahedian-Azimi, SM Mohammadi… - Archives of Medical …, 2021 - ncbi.nlm.nih.gov
Results The final selected studies (n= 24 studies; 32,715 patients) showed significant
reductions in ICU admission (OR= 0.78, 95% CI: 0.58–1.06; n= 10; I 2= 58.5%) and death …
reductions in ICU admission (OR= 0.78, 95% CI: 0.58–1.06; n= 10; I 2= 58.5%) and death …
Genetic screens identify host factors for SARS-CoV-2 and common cold coronaviruses
The Coronaviridae are a family of viruses that cause disease in humans ranging from mild
respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host …
respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host …
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation
Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane
fusion events caused by the same machinery that underlies viral entry. These syncytia are …
fusion events caused by the same machinery that underlies viral entry. These syncytia are …
[HTML][HTML] PoLA/CFPiP/PCS/PSLD/PSD/PSH guidelines on diagnosis and therapy of lipid disorders in Poland 2021
M Banach, P Burchardt, K Chlebus… - Archives of Medical …, 2021 - ncbi.nlm.nih.gov
Moreover, over the last few years the approach to treatment of patients with a high
cardiovascular risk has totally changed from treatment aimed at a specific risk factor (ie …
cardiovascular risk has totally changed from treatment aimed at a specific risk factor (ie …
The role of high cholesterol in age-related COVID19 lethality
Coronavirus disease 2019 (COVID19) is a respiratory infection caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) originating in Wuhan, China in 2019 …
respiratory syndrome coronavirus 2 (SARS-CoV-2) originating in Wuhan, China in 2019 …
Molecular simulations suggest vitamins, retinoids and steroids as ligands of the free fatty acid pocket of the SARS‐CoV‐2 Spike protein
DK Shoemark, CK Colenso, C Toelzer… - Angewandte …, 2021 - Wiley Online Library
We investigate binding of linoleate and other potential ligands to the recently discovered
fatty acid binding site in the SARS‐CoV‐2 spike protein, using docking and molecular …
fatty acid binding site in the SARS‐CoV‐2 spike protein, using docking and molecular …
Time to recovery from COVID-19 and its predictors among patients admitted to treatment center of Wollega University Referral Hospital (WURH), Western Ethiopia …
Introduction Despite its alarming spread throughout the world, no effective drug and vaccine
is discovered for COVID-19 so far. According to WHO, the recovery time from COVID-19 was …
is discovered for COVID-19 so far. According to WHO, the recovery time from COVID-19 was …
[HTML][HTML] Statins reduce mortality in patients with COVID-19: an updated meta-analysis of 147 824 patients
C Diaz-Arocutipa, B Melgar-Talavera… - International Journal of …, 2021 - Elsevier
Objectives There is conflicting evidence about the efficacy of statin use in regard to clinical
outcomes in patients with coronavirus disease 2019 (COVID-19). A systematic review and …
outcomes in patients with coronavirus disease 2019 (COVID-19). A systematic review and …
Simvastatin downregulates the SARS-CoV-2-induced inflammatory response and impairs viral infection through disruption of lipid rafts
Coronavirus disease 2019 (COVID-19) is currently a worldwide emergency caused by
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In observational clinical …
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In observational clinical …