Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
P Godoy, NJ Hewitt, U Albrecht, ME Andersen… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
The PI3K/AKT signaling pathway in cancer: Molecular mechanisms and possible therapeutic interventions
The human body consists of countless cells with the possibility of excessive and
uncontrolled proliferation under certain dysregulated circumstances that could cause …
uncontrolled proliferation under certain dysregulated circumstances that could cause …
From molecular mechanisms to therapeutics: understanding MicroRNA-21 in cancer
J Rhim, W Baek, Y Seo, JH Kim - Cells, 2022 - mdpi.com
MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in regulating
gene expression at a posttranscriptional level. As one of the first discovered oncogenic …
gene expression at a posttranscriptional level. As one of the first discovered oncogenic …
Paving the Rho in cancer metastasis: Rho GTPases and beyond
Malignant carcinomas are often characterized by metastasis, the movement of carcinoma
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …
MicroRNA control of epithelial–mesenchymal transition and metastasis
The great majority of cancer deaths are due to metastasis, which remains a poorly
understood pathological process. The formation of a metastasis reflects a succession of …
understood pathological process. The formation of a metastasis reflects a succession of …
Up-regulation of miR-21 mediates resistance to trastuzumab therapy for breast cancer
Trastuzumab resistance emerges to be a major issue in anti-human epidermal growth factor
receptor 2 (HER2) therapy for breast cancers. Here, we demonstrated that miR-21 …
receptor 2 (HER2) therapy for breast cancers. Here, we demonstrated that miR-21 …
MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach
VN Parikh, RC Jin, S Rabello, N Gulbahce, K White… - Circulation, 2012 - Am Heart Assoc
Background—Pulmonary hypertension (PH) is driven by diverse pathogenic etiologies.
Owing to their pleiotropic actions, microRNA molecules are potential candidates for …
Owing to their pleiotropic actions, microRNA molecules are potential candidates for …
MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells
Background MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs
that regulate gene expression at post-transcriptional level. The recent discovery of the …
that regulate gene expression at post-transcriptional level. The recent discovery of the …
Circulating cell-free microRNAs as clinical cancer biomarkers
V Armand-Labit, A Pradines - Biomolecular concepts, 2017 - degruyter.com
MicroRNAs (miRNAs) are non-coding small RNAs that are master regulators of genic
expression and consequently of many cellular processes. But their expression is often …
expression and consequently of many cellular processes. But their expression is often …
The role of microRNA-21 in the onset and progression of cancer
MicroRNAs (miRNAs), a class of small noncoding RNA, posttranscriptionally regulate the
expression of genes. Aberrant expression of miRNA is reported in various types of cancer …
expression of genes. Aberrant expression of miRNA is reported in various types of cancer …