Antibiotics effective against Gram‐negative ESKAPE pathogens are a critical area of unmet
need. Infections caused by these pathogens are not only difficult to treat but finding new …

Recalcitrant infections pose a serious challenge by prolonging antibiotic therapies and
contributing to the spread of antibiotic resistance, thereby threatening the successful …

Phenotypic variations between individual microbial cells play a key role in the resistance of
microbial pathogens to pharmacotherapies. Nevertheless, little is known about cell …

The interactions between bacteria and bacteriophage have important roles in the global
ecosystem; in turn changes in environmental parameters affect the interactions between …

Antibiotic persistence describes the presence of phenotypic variants within an isogenic
bacterial population that are transiently tolerant to antibiotic treatment. Perturbations of …

One of the deepest branches in the tree of life separates the Archaea from the Bacteria.
These prokaryotic groups have distinct cellular systems including fundamentally different …

Bacteriophages represent an avenue to overcome the current antibiotic resistance crisis, but
evolution of genetic resistance to phages remains a concern. In vitro, bacteria evolve genetic …

Antimicrobial resistance is an urgent threat to human health, and new antibacterial drugs are
desperately needed, as are research tools to aid in their discovery and development …

The interaction between a cell and its environment shapes fundamental intracellular
processes such as cellular metabolism. In most cases growth rate is treated as a proximal …

Antibiotic therapy failure is often caused by the presence of persister cells, which are
metabolically-dormant bacteria capable of surviving exposure to antimicrobials. Under …