Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver
disease worldwide and is strongly associated with the presence of oxidative stress …

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

The contribution of inflammation to the chronic joint disease osteoarthritis (OA) is unclear,
and this lack of clarity is detrimental to efforts to identify therapeutic targets. Here we show …

Lack of immune system cells or impairment in differentiation of immune cells is the basis for
many chronic diseases. Metabolic changes could be the root cause for this immune cell …

Overnutrition and sedentary activity reinforce the growing trend of worldwide obesity, insulin
resistance, and type 2 diabetes. However, we have limited insight into how food intake …

The heart is the most metabolically flexible organ with respect to the use of substrates
available in different states of energy metabolism. Cardiac mitochondria sense substrate …

Mitochondrial dysfunction has been implicated in the pathogenesis of nonalcoholic fatty liver
disease (NAFLD) through poorly defined mechanisms. Melatonin supplementation has been …

Besides their main function for energy production in form of ATP in processes of oxidative
phosphorylation (OxPhos), mitochondria perform many other important cellular functions …

The free radical nitric oxide (· NO) is a key mediator in different physiological processes such
as vasodilation, neurotransmission, inflammation, and cellular immune responses, and thus …

Nitric oxide (NO) is a highly reactive molecule, generated through metabolism of L-arginine
by NO synthase (NOS). Abnormal NO levels in mammalian cells are associated with multiple …