Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …

Bone remodeling is essential for adult bone homeostasis. It comprises two phases: bone
formation and resorption. The balance between the two phases is crucial for sustaining bone …

Regenerative medicine has sparked interest in potential strategies for bone repair. Bone
defects are widespread and could be caused by trauma, congenital malformations …

Calcium phosphates (CaPs) are the most widely used bone substitutes in bone tissue
engineering due to their compositional similarities to bone mineral and excellent …

Mesenchymal stem cells (MSCs) are broadly distributed cells that retain postnatal capacity
for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an …

Rapid vascularization of clinical-size bone grafts is an unsolved challenge in regenerative
medicine. Vascular endothelial growth factor-A (VEGF) is the master regulator of …

Mesenchymal stem cells (MSCs) are a prototypical adult stem cell with capacity for self-
renewal and differentiation with a broad tissue distribution. Initially described in bone …

To date, the delivery of signaling molecules for bone regeneration has focused primarily on
factors that directly affect the bone formation pathways (osteoinduction) or that serve to …

Objectives Our goal is to review design strategies for the fabrication of calcium phosphate
ceramic scaffolds (CPS), in light of their transient role in bone tissue engineering and …

Mesenchymal stem cells (MSCs) have been isolated from bone marrow, periosteum,
trabecular bone, adipose tissue, synovium, skeletal muscle and deciduous teeth. These …