Secondary radiation emission induced by nuclear reactions is correlated to the path of ions
in matter. Therefore, such penetrating radiation can be used for in vivo control of …

Hadron therapy allows for highly conformal dose distributions and better sparing of organs-
at-risk, thanks to the characteristic dose deposition as function of depth. However, the quality …

We present a full-scale clinical prototype system for in vivo range verification of proton pencil-
beams using the prompt gamma-ray spectroscopy method. The detection system consists of …

In proton therapy, patients benefit from the precise deposition of the dose in the tumor
volume due to the interaction of charged particles with matter. Currently, the determination of …

In-vivo range verification has been a hot topic in particle therapy for about two decades. In
spite of vast efforts made by research groups all over the world, clinical devices and …

Owing to the favorable physical and biological properties of swift ions in matter, their
application to radiation therapy for highly selective cancer treatment is rapidly spreading …

Proton beams are promising means for treating tumors. Such charged particles stop at a
defined depth, where the ionization density is maximum. As the dose deposit beyond this …

For the purpose of detecting deviations from the prescribed treatment during particle
therapy, the integrals of uncollimated prompt gamma-ray timing distributions are …

As more and more particle therapy centers are being built world-wide, there is increasing
need in treatment monitoring methods, ideally in real time. This article investigates the …

Ion beam therapy is an emerging modality for high precision radiation treatment of cancer. In
comparison to conventional radiation sources (photons, electrons), ion beams feature major …