Infection, inflammation, tumors, and other illnesses have for a long time posed a major
danger to human health and have developed into a global public health issue. However, the …

With the rising levels of drug resistance, developing efficient antimicrobial therapies has
become a priority. A promising strategy is the conjugation of antibiotics with relevant …

In cystic fibrosis (CF), mutations in the CF transmembrane conductance regulator protein
reduce ionic exchange in the lung, resulting in thicker mucus, which impairs mucociliary …

The evolution and spread of antimicrobial resistance (AMR) is recognized as a major threat
to global health and to healthcare systems, being the cause for almost 700,000 deaths …

New antibiotics are needed as bacterial infections continue to be a leading cause of death,
but efforts to develop compounds with promising antibacterial activity are hindered by a poor …

Redox reactions are ubiquitous in biological processes. Enzymes involved in redox
metabolism often use cofactors in order to facilitate electron-transfer reactions. Common …

The extensive use of antibiotics in medicine and agriculture has resulted in the accumulation
of antibiotic-resistant microorganisms and antibiotic resistance genes (ARGs) in …

Most opportunistic pathogens transit in the environment between hosts and the environment
plays a significant role in the evolution of protective traits. The coincidental evolution …

The cell envelope of Gram-negative bacteria belonging to the Burkholderia cepacia complex
(Bcc) presents unique restrictions to antibiotic penetration. As a consequence, Bcc species …

Since the dawn of space exploration, the survivability of terrestrial life in outer space
conditions has attracted enormous attention. Space technology has enabled the …