Herpesvirus DNA polymerases: Structures, functions and inhibitors
Human herpesviruses are large double-stranded DNA viruses belonging to the
Herpesviridae family. These viruses have the ability to establish lifelong latency into the host …
Herpesviridae family. These viruses have the ability to establish lifelong latency into the host …
Phosphonoformic acid inhibits viral replication by trapping the closed form of the DNA polymerase
Phosphonoformic acid (PFA, foscarnet) belongs to a class of antiviral drugs that inhibit the
human cytomegalovirus DNA polymerase (UL54) by mimicking the pyrophosphate leaving …
human cytomegalovirus DNA polymerase (UL54) by mimicking the pyrophosphate leaving …
Analysis of novel drug-resistant human cytomegalovirus DNA polymerase mutations reveals the role of a DNA-binding loop in phosphonoformic acid resistance
KR Park, YE Kim, A Shamim, S Gong, SH Choi… - Frontiers in …, 2022 - frontiersin.org
The appearance of drug-resistant mutations in UL54 DNA polymerase and UL97 kinase
genes is problematic for the treatment of human cytomegalovirus (HCMV) diseases. During …
genes is problematic for the treatment of human cytomegalovirus (HCMV) diseases. During …
In Vitro-Selected Drug-Resistant Varicella-Zoster Virus Mutants in the Thymidine Kinase and DNA Polymerase Genes Yield Novel Phenotype-Genotype Associations …
G Andrei, D Topalis, P Fiten, C McGuigan… - Journal of …, 2012 - Am Soc Microbiol
Varicella zoster virus (VZV) is usually associated with mild to moderate illness in
immunocompetent patients. However, older age and immune deficiency are the most …
immunocompetent patients. However, older age and immune deficiency are the most …
Selection and recombinant phenotyping of a novel CMX001 and cidofovir resistance mutation in human cytomegalovirus
SH James, NB Price, CB Hartline… - Antimicrobial agents …, 2013 - Am Soc Microbiol
ABSTRACT CMX001 is an orally available lipid acyclic nucleotide phosphonate that delivers
high intracellular levels of cidofovir (CDV)-diphosphate and exhibits enhanced in vitro …
high intracellular levels of cidofovir (CDV)-diphosphate and exhibits enhanced in vitro …
Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet
Selection of human cytomegalovirus variants in the presence of ganciclovir or foscarnet led
to 18 DNA polymerase mutations, 14 of which had not been previously studied. Using …
to 18 DNA polymerase mutations, 14 of which had not been previously studied. Using …
Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene
S Chou - Antiviral research, 2017 - Elsevier
Human cytomegalovirus UL54 DNA polymerase gene mutations that confer foscarnet
resistance in clinical practice typically cluster in the amino terminal 2, palm and finger …
resistance in clinical practice typically cluster in the amino terminal 2, palm and finger …
Contrasting effect of new HCMV pUL54 mutations on antiviral drug susceptibility: benefits and limits of 3D analysis
D Andouard, MC Mazeron, G Ligat, A Couvreux… - Antiviral Research, 2016 - Elsevier
Human cytomegalovirus (HCMV) resistance to antiviral drugs is a major drawback of
repeated or long-duration treatment in immunocompromised patients. Resistance testing is …
repeated or long-duration treatment in immunocompromised patients. Resistance testing is …
Different mutations in the HHV-6 DNA polymerase gene accounting for resistance to foscarnet
P Bonnafous, L Naesens, S Petrella… - Antiviral …, 2007 - journals.sagepub.com
Background Human herpesvirus 6 (HHV-6), which is closely related to human
cytomegalovirus, is sensitive to foscarnet (PFA). Up to now, the resistance of HHV-6 to PFA …
cytomegalovirus, is sensitive to foscarnet (PFA). Up to now, the resistance of HHV-6 to PFA …
Viral DNA polymerase inhibitors
G Andrei, E De Clercq, R Snoeck - Viral genome replication, 2009 - Springer
DNA viruses, as well as their host cells, require a DNA-dependent DNA polymerase to
faithfully replicate their genomes. Viruses with small DNA genomes, such as …
faithfully replicate their genomes. Viruses with small DNA genomes, such as …