Piperazine: Its role in the discovery of pesticides

W Zhang, S Guo, L Yu, Y Wang, YR Chi, J Wu - Chinese Chemical Letters, 2023 - Elsevier
Derivatives of piperazine, which is one of the most important heterocycles, are often used as
linkers to connect active substructures that show promising bioactivities, especially in the …

[HTML][HTML] The versatility of DABCO: synthetic applications of its basic, nucleophilic, and catalytic properties Part 1. Catalysis of Morita–Baylis–Hillman and Knoevenagel …

DI Bugaenko, AV Karchava, MA Yurovskaya - Chemistry of Heterocyclic …, 2020 - Springer
This review article covers literature data from the last 5 years regarding the various
applications of 1, 4-diazabicyclo [2.2. 2] octane (DABCO) in organic chemistry. The frequent …

N-Arylation of DABCO with Diaryliodonium Salts: General Synthesis of N-Aryl-DABCO Salts as Precursors for 1,4-Disubstituted Piperazines

DI Bugaenko, MA Yurovskaya, AV Karchava - Organic letters, 2018 - ACS Publications
Employing DABCO as a substrate, aryl (mesityl) iodonium triflates are introduced as
arylating agents for a tertiary sp3-nitrogen. Mild conditions and exceptional selectivity of the …

Trifluoromethylpyridine piperazine derivatives: synthesis and anti‐plant virus activity

W Zhang, S Guo, Y Wang, Y Wu, L Yu… - Pest Management …, 2023 - Wiley Online Library
BACKGROUND The cucumber mosaic virus (CMV) is well‐known for its expansive host
range and distribution, resulting in a detrimental effect on agricultural production, thus …

DABCO bond cleavage for the synthesis of piperazine derivatives

AZ Halimehjani, E Badali - RSC advances, 2019 - pubs.rsc.org
The applications of DABCO (1, 4-diazabicyclo [2.2. 2] octane) in the synthesis of piperazine
derivatives including biologically active compounds via C–N bond cleavage are investigated …

Sulfonylation of 1, 4‐Diazabicyclo [2.2. 2] octane: Charge‐Transfer Complex Triggered C− N Bond Cleavage

Y Fu, QS Xu, QZ Li, MP Li, CZ Shi, Z Du - ChemistryOpen, 2019 - Wiley Online Library
A novel charge‐transfer complex triggered sulfonylation of 1, 4‐diazabicyclo [2.2. 2] octane
(DABCO) with mild reaction conditions has been developed. The formation of a charge …

Benzyne‐Induced Ring Opening Reactions of DABCO: Synthesis of 1, 4‐Disubstituted Piperazines and Piperidines

J Seo, D Kim, HM Ko - Advanced Synthesis & Catalysis, 2020 - Wiley Online Library
Abstract The 2‐(4‐phenylpiperazin‐1‐yl) ethan‐1‐amine scaffold is a structurally important
motif that occurs frequently in medicinal and pharmaceutical chemistry. Despite the …

Arynes, diaryliodonium salts and azine N-oxides in transition metal-free electrophilic N-arylation

DI Bugaenko, AV Karchava… - Russian Chemical …, 2018 - iopscience.iop.org
The main approach to the synthesis of aromatic and heteroaromatic amines is based on
palladium-and copper-catalyzed N-arylation reactions. Although these methods are highly …

[HTML][HTML] Recent developments in the synthesis of piperazines (microreview)

SS Sajadikhah, M Nassiri - Chemistry of Heterocyclic Compounds, 2021 - Springer
The microreview focuses on the recent methods for the synthesis of piperazine derivatives,
published in 2015–2020. The methods include cyclization of 1, 2-diamine derivatives with …

[HTML][HTML] The versatility of DABCO: synthetic applications of its basic, nucleophilic, and catalytic properties Part 2*. Catalysis of Michael and Biginelli reactions and …

DI Bugaenko, AV Karchava, MA Yurovskaya - Chemistry of Heterocyclic …, 2020 - Springer
The versatility of DABCO: synthetic applications of its basic, nucleophilic, and catalytic
properties Part 2*. Catalysis of Michael and Biginelli reactions and nucleophilic addition at C=X …