Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis
Genetic variation in alpha-1 antitrypsin (AAT) causes AAT deficiency (AATD) through liver
aggregation-associated gain-of-toxic pathology and/or insufficient AAT activity in the lung …
aggregation-associated gain-of-toxic pathology and/or insufficient AAT activity in the lung …
Understanding the host-pathogen evolutionary balance through Gaussian process modeling of SARS-CoV-2
S Loguercio, BC Calverley, C Wang, D Shak, P Zhao… - Patterns, 2023 - cell.com
We have developed a machine learning (ML) approach using Gaussian process (GP)-based
spatial covariance (SCV) to track the impact of spatial-temporal mutational events driving …
spatial covariance (SCV) to track the impact of spatial-temporal mutational events driving …
Computational Tools to Assist in Analyzing Effects of the SERPINA1 Gene Variation on Alpha-1 Antitrypsin (AAT)
J Mróz, M Pelc, K Mitusińska… - Genes, 2024 - mdpi.com
In the rapidly advancing field of bioinformatics, the development and application of
computational tools to predict the effects of single nucleotide variants (SNVs) are shedding …
computational tools to predict the effects of single nucleotide variants (SNVs) are shedding …
Triangulating variation in the population to define mechanisms for precision management of genetic disease
C Wang, F Anglès, WE Balch - Structure, 2022 - cell.com
To understand mechanistically how the protein fold is shaped by therapeutics to inform
precision management of disease, we developed variation-capture (VarC) mapping. VarC …
precision management of disease, we developed variation-capture (VarC) mapping. VarC …