Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …

The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which
is associated with both functional biology and the development of a number of disorders …

The mechanisms underlying ribonucleoprotein (RNP) granule assembly, including the basis
for establishing and maintaining RNP granules with distinct composition, are unknown. One …

Many biomolecular condensates appear to form via spontaneous or driven processes that
have the hallmarks of intracellular phase transitions. This suggests that a common …

Intrinsically disordered protein regions (IDRs)-regions that do not fold into a fixed three-
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …

Intrinsically disordered proteins and protein regions make up a substantial fraction of many
proteomes in which they play a wide variety of essential roles. A critical first step in …

Many biomolecular condensates form via spontaneous phase transitions that are driven by
multivalent proteins. These molecules are biological instantiations of associative polymers …

Proteins that undergo liquid–liquid phase separation (LLPS) have been shown to play a
critical role in many physiological functions through formation of condensed liquid-like …

Under stress, certain eukaryotic proteins and RNA assemble to form membraneless
organelles known as stress granules. The most well-studied stress granule components are …

Compartmentalization by liquid-liquid phase separation (LLPS) has emerged as a
ubiquitous mechanism underlying the organization of biomolecules in space and time. Here …