Big data from small data: data-sharing in the'long tail'of neuroscience

AR Ferguson, JL Nielson, MH Cragin… - Nature …, 2014 - nature.com
The launch of the US BRAIN and European Human Brain Projects coincides with growing
international efforts toward transparency and increased access to publicly funded research …

[HTML][HTML] Neuronal morphology goes digital: a research hub for cellular and system neuroscience

R Parekh, GA Ascoli - Neuron, 2013 - cell.com
The importance of neuronal morphology in brain function has been recognized for over a
century. The broad applicability of" digital reconstructions" of neuron morphology across …

Generative models for network neuroscience: prospects and promise

RF Betzel, DS Bassett - Journal of The Royal Society …, 2017 - royalsocietypublishing.org
Network neuroscience is the emerging discipline concerned with investigating the complex
patterns of interconnections found in neural systems, and identifying principles with which to …

Statistical analysis and data mining of digital reconstructions of dendritic morphologies

S Polavaram, TA Gillette, R Parekh… - Frontiers in …, 2014 - frontiersin.org
Neuronal morphology is diverse among animal species, developmental stages, brain
regions, and cell types. The geometry of individual neurons also varies substantially even …

Data-driven morphological feature perception of single neuron with graph neural network

T Zhu, G Yao, D Hu, C Xie, P Li, X Yang… - … on Medical Imaging, 2023 - ieeexplore.ieee.org
Clarifying the morphological characteristics of neurons can promote the understanding of
brain function. However, traditional morphometrics fail to capture the modeling of each point …

Using Pareto optimality to explore the topology and dynamics of the human connectome

A Avena-Koenigsberger, J Goñi… - … of the Royal …, 2014 - royalsocietypublishing.org
Graph theory has provided a key mathematical framework to analyse the architecture of
human brain networks. This architecture embodies an inherently complex relationship …

Graph representation learning for large-scale neuronal morphological analysis

J Zhao, X Chen, Z Xiong, ZJ Zha… - IEEE Transactions on …, 2022 - ieeexplore.ieee.org
The analysis of neuronal morphological data is essential to investigate the neuronal
properties and brain mechanisms. The complex morphologies, absence of annotations, and …

Quantitative investigations of axonal and dendritic arbors: development, structure, function, and pathology

R Parekh, GA Ascoli - The Neuroscientist, 2015 - journals.sagepub.com
The branching structures of neurons are a long-standing focus of neuroscience. Axonal and
dendritic morphology affect synaptic signaling, integration, and connectivity, and their …

Genotype-specific effects of Mecp2 loss-of-function on morphology of Layer V pyramidal neurons in heterozygous female Rett syndrome model mice

L Rietveld, DP Stuss, D McPhee… - Frontiers in Cellular …, 2015 - frontiersin.org
Rett syndrome (RTT) is a progressive neurological disorder primarily caused by mutations in
the X-linked gene methyl-CpG-binding protein 2 (MECP2). The heterozygous female brain …

Universal features of dendrites through centripetal branch ordering

A Vormberg, F Effenberger, J Muellerleile… - PLoS computational …, 2017 - journals.plos.org
Dendrites form predominantly binary trees that are exquisitely embedded in the networks of
the brain. While neuronal computation is known to depend on the morphology of dendrites …