Cartilage defects are one of the most common symptoms of osteoarthritis (OA), a
degenerative disease that affects millions of people world-wide and places a significant …

Complement activation is associated with common rheumatic diseases such as systemic
lupus erythematosus (SLE), rheumatoid arthritis (RA) and systemic vasculitis. Evidence …

Understanding the causality of the post-traumatic osteoarthritis (PTOA) disease process of
the knee joint is important for diagnosing early disease and developing new and effective …

Inflammation plays a central role in the pathogenesis of knee PTOA after knee trauma. While
a comprehensive therapy capable of preventing or delaying post-traumatic osteoarthritis …

Components of the extracellular matrix (ECM), when exposed to body fluids may promote
local complement activation and inflammation. Pathologic complement activation at the …

Osteoarthritis (OA) is a progressive cartilage degradation disease, concomitant with
synovitis, osteophyte formation, and subchondral bone sclerosis. Over 37% of the elderly …

Objective Inflammation and innate immune responses may contribute to development and
progression of Osteoarthritis (OA). Chondrocytes are the sole cell type of the articular …

This review summarizes and exemplifies the current understanding of osteoarthritis in vitro
models and describes their relevance for new insights in the future of osteoarthritis research …

Background Primary osteoarthritis (OA) is the most common cause of knee arthritis
worldwide. The knee synovial fluid complement C3-β chain levels have been shown to …

Synovitis is a key contributor to the inflammatory environment in osteoarthritis (OA) joints.
Currently, the biological therapy of OA is not satisfactory in multiple single-target trials on …