Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

Nitric oxide production in response to flow-dependent shear forces applied on the surface of
endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral …

Blood vessels respond to changes in mechanical load from circulating blood in the form of
shear stress and mechanical strain as the result of heart propulsions by changes in …

Key points In aged rats, daily muscle stretching increases blood flow to skeletal muscle
during exercise. Daily muscle stretching enhanced endothelium‐dependent vasodilatation …

Abstract In the United States trauma is the leading cause of mortality among those under the
age of 45, claiming approximately 192,000 lives each year. Significant personal disability …

Lung capillary endothelial cells (ECs) are a critical target of oxygen toxicity and play a
central role in the pathogenesis of hyperoxic lung injury. To determine mechanisms and time …

Increased nitric oxide (NO) is the main factor leading to the hyperdynamic circulation
associated with advanced portal hypertension (PHT), but the initial mechanisms and the …

The proportion of patients receiving protective ventilatory strategies remains modest. If
efforts to minimize the iatrogenic consequences of mechanical ventilation are to succeed …

As an interface between the blood flow and vessel wall, endothelial cells (ECs) are exposed
to hemodynamic forces, and the biochemical molecules released from ECs–blood flow …

Mechanical ventilation with high tidal volumes has been associated with pulmonary alveolar
flooding. Understanding the mechanisms underlying cyclic stretch–induced increases in …