[HTML][HTML] Epileptic-network-based prediction and control of seizures in humans

K Lehnertz, T Bröhl, R von Wrede - Neurobiology of Disease, 2023 - Elsevier
Epilepsy is now conceptualized as a network disease. The epileptic brain network
comprises structurally and functionally connected cortical and subcortical brain regions …

Mapping lesion-related epilepsy to a human brain network

FL Schaper, J Nordberg, AL Cohen, C Lin, J Hsu… - JAMA …, 2023 - jamanetwork.com
Importance It remains unclear why lesions in some locations cause epilepsy while others do
not. Identifying the brain regions or networks associated with epilepsy by mapping these …

Closed-loop stimulation in periods with less epileptiform activity drives improved epilepsy outcomes

DN Anderson, CM Charlebois, EH Smith, TS Davis… - Brain, 2024 - academic.oup.com
In patients with drug-resistant epilepsy, electrical stimulation of the brain in response to
epileptiform activity can make seizures less frequent and debilitating. This therapy, known as …

Revisiting the concept of drug‐resistant epilepsy: a TASK1 report of the ILAE/AES Joint Translational Task Force

S Auvin, AS Galanopoulou, SL Moshé, H Potschka… - …, 2023 - Wiley Online Library
Despite progress in the development of anti‐seizure medications (ASMs), one third of
people with epilepsy have drug‐resistant epilepsy (DRE). The working definition of DRE …

Intracranial EEG structure-function coupling and seizure outcomes after epilepsy surgery

N Sinha, JS Duncan, B Diehl, FA Chowdhury… - Neurology, 2023 - AAN Enterprises
Background and Objectives Surgery is an effective treatment for drug-resistant epilepsy,
which modifies the brain's structure and networks to regulate seizure activity. Our objective …

[HTML][HTML] Generalisability of epileptiform patterns across time and patients

H Karimi-Rouzbahani, A McGonigal - Scientific Reports, 2024 - nature.com
The complexity of localising the epileptogenic zone (EZ) contributes to surgical resection
failures in achieving seizure freedom. The distinct patterns of epileptiform activity during …

[HTML][HTML] Reproducible network changes occur in a mouse model of temporal lobe epilepsy but do not correlate with disease severity

I Rigoni, GP Padmasola, L Sheybani, K Schaller… - Neurobiology of …, 2024 - Elsevier
Studying the development of brain network disruptions in epilepsy is challenged by the
paucity of data before epilepsy onset. Here, we used the unilateral, kainate mouse model of …

Atypical connectome topography and signal flow in temporal lobe epilepsy

K Xie, J Royer, S Larivière, R Rodriguez-Cruces… - Progress in …, 2024 - Elsevier
Temporal lobe epilepsy (TLE) is the most common pharmaco-resistant epilepsy in adults.
While primarily associated with mesiotemporal pathology, recent evidence suggests that …

[HTML][HTML] Physiological and pathological neuronal connectivity in the living human brain based on intracranial EEG signals: the current state of research

Y Novitskaya, M Dümpelmann… - Frontiers in Network …, 2023 - frontiersin.org
Over the past decades, studies of human brain networks have received growing attention as
the assessment and modelling of connectivity in the brain is a topic of high impact with …

[HTML][HTML] Alterations in brain network functional connectivity and topological properties in DRE patients

Y Ding, K Guo, J Li, Q Shan, Y Guo, M Chen… - Frontiers in …, 2023 - frontiersin.org
Objective The study aimed to find the difference in functional network topology on interictal
electroencephalographic (EEG) between patients with drug-resistant epilepsy (DRE) and …