Scaling up genetic circuit design for cellular computing: advances and prospects

Y Xiang, N Dalchau, B Wang - Natural computing, 2018 - Springer
Synthetic biology aims to engineer and redesign biological systems for useful real-world
applications in biomanufacturing, biosensing and biotherapy following a typical design-build …

Cell-free synthetic biology platform for engineering synthetic biological circuits and systems

D Jeong, M Klocke, S Agarwal, J Kim, S Choi… - Methods and …, 2019 - mdpi.com
Synthetic biology integrates diverse engineering disciplines to create novel biological
systems for biomedical and technological applications. The substantial growth of the …

Deep learning to predict the lab-of-origin of engineered DNA

AAK Nielsen, CA Voigt - Nature communications, 2018 - nature.com
Genetic engineering projects are rapidly growing in scale and complexity, driven by new
tools to design and construct DNA. There is increasing concern that widened access to …

Cell-free protein synthesis as a prototyping platform for mammalian synthetic biology

MB Kopniczky, C Canavan, DW McClymont… - ACS synthetic …, 2020 - ACS Publications
The field of mammalian synthetic biology is expanding quickly, and technologies for
engineering large synthetic gene circuits are increasingly accessible. However, for …

GOLDBAR: A Framework for Combinatorial Biological Design

N Roehner, J Roberts, A Lapets, D Gould… - ACS Synthetic …, 2024 - ACS Publications
With the rise of new DNA part libraries and technologies for assembling DNA, synthetic
biologists are increasingly constructing and screening combinatorial libraries to optimize …

Engineered living conductive biofilms as functional materials

LJ Bird, EL Onderko, DA Phillips, RL Mickol… - MRS …, 2019 - cambridge.org
Natural living conductive biofilms transport electrons between electrodes and cells, as well
as among cells fixed within the film, catalyzing an array of reactions from acetate oxidation to …

Automated robotic liquid handling assembly of modular DNA devices

L Ortiz, M Pavan, L McCarthy… - Journal of …, 2017 - pmc.ncbi.nlm.nih.gov
Recent advances in modular DNA assembly techniques have enabled synthetic biologists to
test significantly more of the available" design space" represented by" devices" created as …

A synthetic distributed genetic multi-bit counter

T Chen, MA Al-Radhawi, CA Voigt, ED Sontag - IScience, 2021 - cell.com
A design for genetically encoded counters is proposed via repressor-based circuits. An N-bit
counter reads sequences of input pulses and displays the total number of pulses, modulo 2 …

Boosting secondary metabolite production and discovery through the engineering of novel microbial biosensors

UA de Frias, GKB Pereira… - BioMed research …, 2018 - Wiley Online Library
Bacteria are a source of a large number of secondary metabolites with several biomedical
and biotechnological applications. In recent years, there has been tremendous progress in …

Characterization of Programmable Transcription Activators in the Model Monocot Setaria viridis Via Protoplast Transfection

A Sychla, JA Casas-Mollano, MH Zinselmeier… - … : Methods and Protocols, 2022 - Springer
Recent advances in DNA synthesis and assembly allow for genetic constructs to be
designed and constructed in high throughput. Characterizing large numbers of variant …