There is a broad consensus that multiple sclerosis (MS) represents more than an
inflammatory disease: it harbors several characteristic aspects of a classical …

Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease that affects the
central nervous system and represents the most common neurological disorder in young …

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system. Various pre-clinical models with different specific features of the disease …

The central nervous system (CNS) is immune privileged with access to leukocytes being
limited. In several neurological diseases, however, infiltration of immune cells from the …

Introduction: Demyelinating diseases of the central nervous system (CNS) comprise a group
of neurological disorders characterized by progressive (and eventually irreversible) loss of …

The copper chelator cuprizone (bis-cyclohexanone oxaldihydrazone) was established as a
neurotoxin in rodents in 1966 by Carlton. During the following years the usefulness of …

Multiple sclerosis is a chronic demyelinating disease of the central nervous system.
Spontaneous remyelination during early disease stages is thought to preserve and partially …

The effect of redox metals such as iron and copper on multiple sclerosis and amyotrophic
lateral sclerosis has been intensively studied. However, the origin of these disorders …

In multiple sclerosis (MS), gray matter pathology is characterized by less pronounced
inflammation when compared with white matter lesions. Although regional differences in the …

Over the past several decades, significant advances have been made in identifying factors
that contribute to the pathogenesis of multiple sclerosis (MS) and have culminated in the …