Synthesis, molecular modelling studies and ADME prediction of benzothiazole clubbed oxadiazole-Mannich bases, and evaluation of their anti-diabetic activity …

R Bhutani, DP Pathak, G Kapoor, A Husain, R Kant… - Bioorganic …, 2018 - Elsevier
A small library of new benzothiazole clubbed oxadiazole-Mannich bases (M-1 to M-22) were
synthesized and characterized by IR, NMR, Mass and Elemental analysis results. Molecular …

[PDF][PDF] Benzothiazole-Versatile heterocyclic nucleus in medicinal chemistry: A review

GN Raju, BS Karumudi, NR Rao - Int. J. Pharm. Chem, 2015 - Citeseer
Benzothiazole, the bicyclic ring system consists of thiazole ring fused with benzene ring.
Benzothiazole moiety is very small but is fascinated by scientists because of the different …

[HTML][HTML] Design, synthesis, molecular docking and anticonvulsant evaluation of novel 6-iodo-2-phenyl-3-substituted-quinazolin-4 (3H)-ones

MK Ibrahim, K El-Adl, AA Al-Karmalawy - Bulletin of Faculty of Pharmacy …, 2015 - Elsevier
A new series of 6-iodo-2-phenyl-3-substituted-quinazolin-4 (3H)-one (5–12 a–b) derivatives
were synthesized, evaluated for their anticonvulsant activity against pentylenetetrazole …

State of the art review and report of new tool for drug discovery

Y Martinez-Lopez, Y Caballero… - Current topics in …, 2017 - ingentaconnect.com
Background: There are a great number of tools that can be used in QSAR/QSPR studies;
they are implemented in several programs that are reviewed in this report. The usefulness of …

Synthesis, modelling, and anticonvulsant studies of new quinazolines showing three highly active compounds with low toxicity and high affinity to the GABA-A receptor

MF Zayed, SK Ihmaid, HEA Ahmed, K El-Adl, AM Asiri… - Molecules, 2017 - mdpi.com
Some novel fluorinated quinazolines (5a–j) were designed and synthesized to be evaluated
for their anticonvulsant activity and their neurotoxicity. Structures of all newly synthesized …

[PDF][PDF] Molecular docking, synthesis and biological evaluation of some novel 2-substituted-3-allyl-4 (3H)-quinazolinone derivatives as anticonvulsant agents

HS Abulkhair, KM El-Gamal, K El-Adl, MF Fadl - Med. Chem, 2016 - researchgate.net
A new series of 2-substituted-3-allyl-4 (3H)-quinazolinone derivatives (4a-e-8a-d) were
synthesized and evaluated for their anticonvulsant activity against pentylenetetrazole (PTZ) …

Unveiling the Anti-convulsant Potential of Novel Series of 1, 2, 4-Triazine-6H-Indolo [2, 3-b] quinoline Derivatives: In Silico Molecular Docking, ADMET, DFT, and …

H Singh, D Pathak - Current Computer-Aided Drug Design, 2024 - ingentaconnect.com
Background: Epilepsy is a chronic neurological disorder caused by irregular electrical
activity in the brain. To manage this disorder effectively, it is imperative to identify potential …

Synthesis, molecular docking, and biological evaluation of some novel 2-(5-substituted 1, 3, 4-oxadiazole-2-yl)-1, 3-benzothiazole Derivatives as Anticonvulsant …

SL Khokra, S Kaur, S Banwala… - … System Agents in …, 2021 - ingentaconnect.com
Background: Benzothiazole is an organosulfur heterocyclic compound that has a
considerable place in drug discovery due to significant pharmacological actions. Objective …

A Mini Review on Recent Advancements in the Therapeutic Potentials of Benzothiazoles

R Bhutani, G Kapoor, DP Pathak… - Current Bioactive …, 2021 - ingentaconnect.com
Among the various fused heterocyclic rings, benzothiazole and its analogs have been
explored broadly in search of newer therapeutic medicinal agents. The benzothiazole …

[PDF][PDF] A Review: Synthesis and Pharmacological Profile of [1, 5]-Benzothiazepine

S Khasimbi, F Ali, SW Kumari Neha… - Letters in Organic …, 2020 - researchgate.net
The 1, 5-benzothiazepine derivatives are of particular interest for lead discovery since they
have been found active against different families of targets. 1, 5-Benzothaizepines …