Enterochromaffin (EC) cells synthesize 95% of the body 5-HT and release 5-HT in response
to mechanical or chemical stimulation. EC cell 5-HT has physiological effects on gut motility …

Purinergic signalling plays major roles in the physiology and pathophysiology of digestive
organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive …

Enterochromaffin (EC) cells constitute the largest population of intestinal epithelial
enteroendocrine (EE) cells. EC cells are proposed to be specialized mechanosensory cells …

Key points The gastrointestinal epithelial enterochromaffin (EC) cell synthesizes the vast
majority of the body's serotonin. As a specialized mechanosensor, the EC cell releases this …

Sensation of mechanical forces is critical for normal function of the gastrointestinal (GI) tract
and abnormalities in mechanosensation are linked to GI pathologies. In the GI tract there are …

Background Clinical observations or animal studies implicate enteric glial cells in motility
disorders, irritable bowel syndrome, inflammatory bowel disease, gastrointestinal (GI) …

Enterochromaffin (EC) cells are the primary mechanosensors of the gastrointestinal (GI)
epithelium. In response to mechanical stimuliEC cells release serotonin (5 …

Purinergic receptors play an important role in inflammation, and can be activated by ATP
released via pannexin channels and/or connexin hemichannels. The purinergic P2X7 …

The role of endogenous serotonin (5‐HT) in gastrointestinal motility is still highly
controversial. Although electrochemical techniques allow for direct and real‐time recording …

Treatments for inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), functional
dyspepsia, or motility disorders are not adequate, and purinergic drugs offer exciting new …