The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular
processes, including the regulation of transcription, apoptosis and the DNA damage …

In the past period, due to the rapid development of next-generation sequencing technology,
accumulating evidence has clarified the complex role of the human microbiota in the …

DNA double-strand breaks (DSBs) are highly deleterious, with a single unrepaired DSB
being sufficient to trigger cell death. Compared to healthy cells, cancer cells have a higher …

DNA double-strand breaks pose a serious threat to genome stability. In vertebrates, these
breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA …

Genomic stability in normal cells is crucial to avoid oncogenesis. Accordingly, multiple
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …

DNA damage is a double-edged sword in cancer cells. On the one hand, DNA damage
exacerbates gene mutation frequency and cancer risk. Mutations in key DNA repair genes …

Double-strand breaks are one of the most deleterious DNA lesions. Their repair via error-
prone mechanisms can promote mutagenesis, loss of genetic information, and deregulation …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1, also known as ADPRT1) is a
multifunctional human ADP-ribosyltransferase. It plays a role in multiple DNA repair …

Oral cancer is a sub-category of head and neck cancers that primarily initiates in the oral
cavity. The primary treatment option for oral cancer remains surgery but it is associated with …

Repair of DNA double-strand breaks (DSB) is performed by two major pathways, homology-
dependent repair and classical nonhomologous end-joining. Recent studies have identified …