Evolutionary pathways and trajectories in antibiotic resistance
Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …
provided a wealth of information, but knowledge regarding “what happened” has precluded …
Evolutionary constraint and innovation across hundreds of placental mammals
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
Retrotransposon renaissance in early embryos
Despite being the predominant genetic elements in mammalian genomes, retrotransposons
were often dismissed as genomic parasites with ambiguous biological significance …
were often dismissed as genomic parasites with ambiguous biological significance …
Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization
M Yu, X Hu, Z Pan, C Du, J Jiang, W Zheng… - Nucleic Acids …, 2023 - academic.oup.com
Endogenous retroviruses (ERVs) have been proposed as a driving force for the evolution of
the mammalian placenta, however, the contribution of ERVs to placental development and …
the mammalian placenta, however, the contribution of ERVs to placental development and …
A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer's disease
F Macciardi, M Giulia Bacalini, R Miramontes… - GeroScience, 2022 - Springer
Recent reports have suggested that the reactivation of otherwise transcriptionally silent
transposable elements (TEs) might induce brain degeneration, either by dysregulating the …
transposable elements (TEs) might induce brain degeneration, either by dysregulating the …
[HTML][HTML] Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression
Transposable elements (TEs) are widespread genetic parasites known to be kept under tight
transcriptional control. Here, we describe a functional connection between the mouse …
transcriptional control. Here, we describe a functional connection between the mouse …
A butterfly pan-genome reveals that a large amount of structural variation underlies the evolution of chromatin accessibility
Despite insertions and deletions being the most common structural variants (SVs) found
across genomes, not much is known about how much these SVs vary within populations and …
across genomes, not much is known about how much these SVs vary within populations and …
Jump-starting life: balancing transposable element co-option and genome integrity in the developing mammalian embryo
ME Oomen, ME Torres-Padilla - EMBO reports, 2024 - embopress.org
Remnants of transposable elements (TEs) are widely expressed throughout mammalian
embryo development. Originally infesting our genomes as selfish elements and acting as a …
embryo development. Originally infesting our genomes as selfish elements and acting as a …
昆虫抗药性相关细胞色素P450 基因的表达调控机制
朱江， 邱星辉 - 昆虫学报, 2021 - insect.org.cn
杀虫剂的频繁持续使用, 必然导致昆虫产生抗药性. 大量研究事例表明参与杀虫剂解毒的细胞
色素P450 (简称P450) 过量表达是昆虫对不同类型杀虫剂产生抗性的重要原因 …
色素P450 (简称P450) 过量表达是昆虫对不同类型杀虫剂产生抗性的重要原因 …
Comprehensive In Silico Analysis of Retrotransposon Insertions within the Survival Motor Neuron Genes Involved in Spinal Muscular Atrophy
Simple Summary Transposable elements are DNA sequences that can move throughout the
genome. They play essential roles in gene regulation and function. Spinal muscular atrophy …
genome. They play essential roles in gene regulation and function. Spinal muscular atrophy …