[PDF][PDF] Extrahepatic replication of HCV: insights into clinical manifestations and biological consequences

JT Blackard, N Kemmer, KE Sherman - Hepatology, 2006 - Wiley Online Library
An estimated 170 million persons are infected with the hepatitis C virus (HCV) worldwide.
While hepatocytes are the major site of infection, a broad clinical spectrum of extrahepatic …

Cognitive dysfunction in chronic hepatitis C: a review

W Perry, RC Hilsabeck, TI Hassanein - Digestive diseases and sciences, 2008 - Springer
The hepatitis C virus (HCV) is a common blood-borne illness that affects up to 2% of the
world's population and almost 4 million Americans. Cognitive impairment, or difficulty with …

Cytokines induced neutrophil extracellular traps formation: implication for the inflammatory disease condition

RS Keshari, A Jyoti, M Dubey, N Kothari, M Kohli… - PloS one, 2012 - journals.plos.org
Neutrophils (PMNs) and cytokines have a critical role to play in host defense and systemic
inflammatory response syndrome (SIRS). Neutrophil extracellular traps (NETs) have been …

[PDF][PDF] Persistence of hepatitis C virus in patients successfully treated for chronic hepatitis C

M Radkowski, JF Gallegos‐Orozco, J Jablonska… - …, 2005 - Wiley Online Library
It is unclear whether the current antiviral treatment for chronic hepatitis C virus (HCV)
infection results in complete elimination of the virus, or whether small quantities of virus …

Hepatitis C virus neuroinvasion: identification of infected cells

J Wilkinson, M Radkowski, T Laskus - Journal of virology, 2009 - Am Soc Microbiol
Hepatitis C virus (HCV) infection often is associated with cognitive dysfunction and
depression. HCV sequences and replicative forms were detected in autopsy brain tissue …

Hepatitis C virus RNA localization in human carotid plaques

M Boddi, R Abbate, B Chellini, B Giusti… - Journal of Clinical …, 2010 - Elsevier
BACKGROUND: Hepatitis C virus (HCV) infection has certain characteristics that enable it to
play an important role in atherosclerosis. Some studies report its association with an …

Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells

K Machida, KTH Cheng, N Pavio, VMH Sung… - Journal of …, 2005 - Am Soc Microbiol
Hepatitis C virus (HCV) is one of the leading causes of chronic liver diseases and B-
lymphocyte proliferative disorders, including mixed cryoglobulinemia and B-cell lymphoma …

Emerging evidence of hepatitis C virus neuroinvasion

T Laskus, M Radkowski, DM Adair, J Wilkinson… - Aids, 2005 - journals.lww.com
It has been reported that hepatitis C virus (HCV) infection is associated with cognitive
dysfunction, fatigue and depression, which do not correlate with the severity of liver disease …

[PDF][PDF] Cross‐presentation of antigen by diverse subsets of murine liver cells

MR Ebrahimkhani, I Mohar, IN Crispe - Hepatology, 2011 - Wiley Online Library
Antigen cross‐presentation is a principal function of specialized antigen‐presenting cells of
bone marrow origin such as dendritic cells. Although these cells are sometimes known as …

Activation of brain macrophages/microglia cells in hepatitis C infection

J Wilkinson, M Radkowski, JM Eschbacher, T Laskus - Gut, 2010 - gut.bmj.com
Objectives Hepatitis C virus (HCV) infection is commonly associated with cognitive
dysfunction. Viral sequences and proteins were previously found in brain …