The principles of inter‐species dose extrapolation are poorly understood and applied. We
provide an overview of the principles underlying dose scaling for size and dose adjustment …

The application of physiologically-based pharmacokinetic (PBPK) modeling is coming of
age in drug development and regulation, reflecting significant advances over the past 10 …

Comprehensive molecular‐level models of human metabolism have been generated on a
cellular level. However, models of whole‐body metabolism have not been established as …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

We describe a human “Body‐on‐a‐chip” device (or microphysiological system) that could be
used to emulate drug distribution, metabolism, and action in the body. It is based upon a …

Advances in bio-mimetic in vitro human skin models increase the efficiency of drug
screening studies. In this study, we designed and developed a microfluidic platform that …

The use of nanoparticles in medical applications is highly anticipated, and at the same time
little is known about how these nanoparticles affect human tissues. Here we have simulated …

This review summarizes the current knowledge on anatomy and physiology of the human
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …

Advances in maintaining multiple human tissues on microfluidic platforms has led to a
growing interest in the development of microphysiological systems for drug development …

We have developed an expandable modular body-on-a-chip system that allows for a plug-
and-play approach with several in vitro tissues. The design consists of single-organ chips …