Diversity of dopaminergic neural circuits in response to drug exposure
Addictive substances are known to increase dopaminergic signaling in the
mesocorticolimbic system. The origin of this dopamine (DA) signaling originates in the …
mesocorticolimbic system. The origin of this dopamine (DA) signaling originates in the …
Generation of ventralized human thalamic organoids with thalamic reticular nucleus
Human brain organoids provide unique platforms for modeling several aspects of human
brain development and pathology. However, current brain organoid systems mostly lack the …
brain development and pathology. However, current brain organoid systems mostly lack the …
The intersection of stress and reward: BNST modulation of aversive and appetitive states
The bed nucleus of the stria terminalis (BNST) is widely acknowledged as a brain structure
that regulates stress and anxiety states, as well as aversive and appetitive behaviours. The …
that regulates stress and anxiety states, as well as aversive and appetitive behaviours. The …
Phasic dopamine release in appetitive behaviors and drug addiction
Although dopamine is implicated in the development of addiction, it is unclear how specific
dopamine release patterns are involved with drug seeking. Addictive drugs increase tonic …
dopamine release patterns are involved with drug seeking. Addictive drugs increase tonic …
A review of the interactions between alcohol and the endocannabinoid system: implications for alcohol dependence and future directions for research
MJ Pava, JJ Woodward - Alcohol, 2012 - Elsevier
Over the past fifty years a significant body of evidence has been compiled suggesting an
interaction between the endocannabinoid (EC) system and alcohol dependence. However …
interaction between the endocannabinoid (EC) system and alcohol dependence. However …
Biochemical and neurotransmitter changes implicated in alcohol-induced brain damage in chronic or 'binge drinking'alcohol abuse
RJ Ward, F Lallemand, P De Witte - Alcohol & Alcoholism, 2009 - academic.oup.com
The brain damage, which occurs after either chronic alcoholization or binge drinking
regimes, shows distinct biochemical and neurotransmitter differences. An excessive amount …
regimes, shows distinct biochemical and neurotransmitter differences. An excessive amount …
Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs
H Morikawa, RA Morrisett - International review of neurobiology, 2010 - Elsevier
The dopaminergic system originating in the midbrain ventral tegmental area (VTA) has been
extensively studied over the past decades as a critical neural substrate involved in the …
extensively studied over the past decades as a critical neural substrate involved in the …
MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption
E Darcq, V Warnault, K Phamluong, GM Besserer… - Molecular …, 2015 - nature.com
MicroRNAs (miRNAs) induce messenger RNA (mRNA) degradation and repress mRNA
translation. Several miRNAs control the expression of the brain-derived neurotrophic factor …
translation. Several miRNAs control the expression of the brain-derived neurotrophic factor …
Chronic intermittent ethanol exposure enhances the excitability and synaptic plasticity of lateral orbitofrontal cortex neurons and induces a tolerance to the acute …
S Nimitvilai, MF Lopez, PJ Mulholland… - …, 2016 - nature.com
Alcoholism is associated with changes in brain reward and control systems, including the
prefrontal cortex. In prefrontal areas, the orbitofrontal cortex (OFC) has been suggested to …
prefrontal cortex. In prefrontal areas, the orbitofrontal cortex (OFC) has been suggested to …