Mitochondrial dysfunction and neurological disorders: a narrative review and treatment overview

EE Alshial, MI Abdulghaney, AHS Wadan… - Life Sciences, 2023 - Elsevier
Mitochondria play a vital role in the nervous system, as they are responsible for generating
energy in the form of ATP and regulating cellular processes such as calcium (Ca 2+) …

Mangosteen pericarp and its bioactive xanthones: Potential therapeutic value in Alzheimer's disease, Parkinson's disease, and depression with pharmacokinetic and …

HTT Do, J Cho - International journal of molecular sciences, 2020 - mdpi.com
Alzheimer's disease (AD), Parkinson's disease (PD), and depression are growing burdens
for society globally, partly due to a lack of effective treatments. Mangosteen (Garcinia …

Efficacy, safety, and tolerability of ansofaxine (LY03005) extended-release tablet for major depressive disorder: a randomized, double-blind, placebo-controlled, dose …

W Mi, F Yang, H Li, X Xu, L Li, Q Tan… - International Journal …, 2022 - academic.oup.com
Abstract Background Ansofaxine (LY03005) extended-release tablet is a potential triple
reuptake inhibitor of serotonin, norepinephrine, and dopamine. This study assessed the …

Gut brain interaction theory reveals gut microbiota mediated neurogenesis and traditional Chinese medicine research strategies

C Zhang, P Xue, H Zhang, C Tan, S Zhao… - Frontiers in Cellular …, 2022 - frontiersin.org
Adult neurogenesis is the process of differentiation of neural stem cells (NSCs) into neurons
and glial cells in certain areas of the adult brain. Defects in neurogenesis can lead to …

The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia

MM Ashton, OM Dean, AJ Walker, CC Bortolasci… - Frontiers in …, 2019 - frontiersin.org
New treatments are urgently needed for serious mental illnesses including bipolar disorder
and schizophrenia. This review proposes that Garcinia mangostana Linn.(mangosteen) …

Induction of stress resistance and extension of lifespan in Chaenorhabditis elegans serotonin-receptor knockout strains by withanolide A

J Naß, S Abdelfatah, T Efferth - Phytomedicine, 2021 - Elsevier
Introduction Approximately 300 million people worldwide suffer from depression. The COVID-
19 crisis may dramatically increase these numbers. Severe side effects and resistance …

Studies on Haloperidol and Adjunctive α-Mangostin or Raw Garcinia mangostana Linn Pericarp on Bio-Behavioral Markers in an Immune-Inflammatory Model of …

J Lotter, M Möller, O Dean, M Berk… - Frontiers in Psychiatry, 2020 - frontiersin.org
Schizophrenia is a severe brain disorder that is associated with neurodevelopmental insults,
such as prenatal inflammation, that introduce redox-immune-inflammatory alterations and …

Pharmacological effects of Garcinia mangostana L.: an update review

R Mahmudah, IK Adnyana… - Research Journal of …, 2020 - search.proquest.com
Garcinia mangostana Linn. or mangosteen through various parts of the plant and its
contents are widely used as an alternative medicine for various diseases by assessing their …

Adjunctive Garcinia mangostana Linn. (Mangosteen) Pericarp for Schizophrenia: A 24-Week Double-blind, Randomized, Placebo Controlled Efficacy Trial: Péricarpe …

A Turner, A Baker, OM Dean… - The Canadian …, 2021 - journals.sagepub.com
Objectives: Garcinia mangostana Linn.(“mangosteen”) pericarp contains bioactive
compounds that may target biological pathways implicated in schizophrenia. We conducted …

Munich, Germany Schizophrenia is a severe brain disorder that is associated with neurodevelopmental insults, such as prenatal inflammation, that introduce redox …

J Lotter, M Möller, O Dean, M Berk… - The Role of …, 2020 - books.google.com
Munich, Germany Schizophrenia is a severe brain disorder that is associated with
neurodevelopmental insults, such as prenatal inflammation, that introduce redox-immune-inflammatory …