Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
B Wang, L Wu, J Chen, L Dong, C Chen… - Signal transduction and …, 2021 - nature.com
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
Mechanisms of phytonutrient modulation of cyclooxygenase-2 (COX-2) and inflammation related to cancer
SJ Desai, B Prickril, A Rasooly - Nutrition and cancer, 2018 - Taylor & Francis
The link between chronic inflammation and cancer involves cytokines and mediators of
inflammatory pathways. Cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism …
inflammatory pathways. Cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism …
Perspectives of the application of non-steroidal anti-inflammatory drugs in cancer therapy: Attempts to overcome their unfavorable side effects
V Thiruchenthooran, E Sánchez-López, A Gliszczyńska - Cancers, 2023 - mdpi.com
Simple Summary The application of non-steroidal anti-inflammatory drugs (NSAIDs) in
cancer therapy has been a widely studied topic for almost four decades. This review …
cancer therapy has been a widely studied topic for almost four decades. This review …
Two-pronged approach to anti-inflammatory therapy through the modulation of the arachidonic acid cascade
Chronic inflammation and pain is a major global health problem, and nonsteroidal anti-
inflammatory drugs (NSAIDs) remain the most frequently prescribed drugs and common …
inflammatory drugs (NSAIDs) remain the most frequently prescribed drugs and common …
A review on the role of fatty acids in colorectal cancer progression
M Hoxha, B Zappacosta - Frontiers in Pharmacology, 2022 - frontiersin.org
Colorectal cancer (CRC) is the third leading cause of mortality in cancer patients. The role of
fatty acids (FA) and their metabolism in cancer, particularly in CRC raises a growing interest …
fatty acids (FA) and their metabolism in cancer, particularly in CRC raises a growing interest …
“Force-from-lipids” gating of mechanosensitive channels modulated by PUFAs
The level of fatty acid saturation in phospholipids is a crucial determinant of the biophysical
properties of the lipid bilayer. Integral membrane proteins are sensitive to changes of their …
properties of the lipid bilayer. Integral membrane proteins are sensitive to changes of their …
The Role of Specialized Pro-Resolving Lipid Mediators in Inflammation-Induced Carcinogenesis
W Torres, JL Pérez, MP Díaz, L D'Marco… - International Journal of …, 2023 - mdpi.com
Cancer is a process involving cell mutation, increased proliferation, invasion, and
metastasis. Over the years, this condition has represented one of the most concerning health …
metastasis. Over the years, this condition has represented one of the most concerning health …
Oleic acid, cholesterol, and linoleic acid as angiogenesis initiators
FP Samson, AT Patrick, TE Fabunmi, MF Yahaya… - ACS …, 2020 - ACS Publications
The current study determined the natural angiogenic molecules using an unbiased
metabolomics approach. A chick chorioallantoic membrane (CAM) model was used to …
metabolomics approach. A chick chorioallantoic membrane (CAM) model was used to …
Modulation of Ras/ERK and phosphoinositide signaling by long-chain n-3 PUFA in breast cancer and their potential complementary role in combination with targeted …
S Serini, G Calviello - Nutrients, 2017 - mdpi.com
A potential complementary role of the dietary long-chain n-3 polyunsaturated fatty acids
(LCn-3 PUFA) in combination with innovative mono-targeted therapies has recently been …
(LCn-3 PUFA) in combination with innovative mono-targeted therapies has recently been …
Role of omega-3 polyunsaturated fatty acids in preventing gastrointestinal cancers: current status and future perspectives
HJ Lee, YM Han, JM An, EA Kang, YJ Park… - Expert review of …, 2018 - Taylor & Francis
Introduction: Although inflammation is defensive and healing process that maintains organ
homeostasis, unresolved inflammation can lead to diseases. Polyunsaturated fatty acids …
homeostasis, unresolved inflammation can lead to diseases. Polyunsaturated fatty acids …