Delivery systems for nucleic acids and proteins: Barriers, cell capture pathways and nanocarriers

JD Torres-Vanegas, JC Cruz, LH Reyes - Pharmaceutics, 2021 - mdpi.com
Gene therapy has been used as a potential approach to address the diagnosis and
treatment of genetic diseases and inherited disorders. In this line, non-viral systems have …

Tailoring iron oxide nanoparticles for efficient cellular internalization and endosomal escape

L Rueda-Gensini, J Cifuentes, MC Castellanos… - Nanomaterials, 2020 - mdpi.com
Iron oxide nanoparticles (IONs) have been widely explored for biomedical applications due
to their high biocompatibility, surface-coating versatility, and superparamagnetic properties …

Biomimetic lipopolysaccharide‐free bacterial outer membrane‐functionalized nanoparticles for brain‐targeted drug delivery

H Chen, M Zhou, Y Zeng, T Miao, H Luo… - Advanced …, 2022 - Wiley Online Library
The blood–brain barrier (BBB) severely blocks the intracranial accumulation of most
systemic drugs. Inspired by the contribution of the bacterial outer membrane to Escherichia …

Treatment of wastewater, phenols and dyes using novel magnetic torus microreactors and laccase immobilized on magnetite nanoparticles

PA Peñaranda, MJ Noguera, SL Florez, J Husserl… - Nanomaterials, 2022 - mdpi.com
In this work, the design, manufacture, and testing of three different magnetic microreactors
based on torus geometries (ie, one-loop, two-horizontal-loop, and two-vertical-loop) is …

Efficient CRISPR/Cas9 nickase-mediated genome editing in an in vitro model of mucopolysaccharidosis IVA

AF Leal, CJ Alméciga-Díaz - Gene Therapy, 2023 - nature.com
Abstract Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disorder (LSD)
caused by mutations in gene encoding for GALNS enzyme. Lack of GALNS activity leads to …

Multifunctional magnetite nanoparticles to enable delivery of siRNA for the potential treatment of Alzheimer's

N Lopez-Barbosa, JG Garcia, J Cifuentes… - Drug Delivery, 2020 - Taylor & Francis
Therapeutic drugs for Alzheimer's disease have been extensively studied due to its
recurrence and abundance among neurodegenerative diseases. It is thought that the …

The landscape of CRISPR/Cas9 for inborn errors of metabolism

AF Leal, N Fnu, E Benincore-Flórez… - Molecular genetics and …, 2023 - Elsevier
Since its discovery as a genome editing tool, the clustered regularly interspaced short
palindromic repeats and CRISPR-associated protein 9 (CRISPR/Cas9) system has opened …

Microfluidic synthesis and purification of magnetoliposomes for potential applications in the gastrointestinal delivery of difficult-to-transport drugs

CE Torres, J Cifuentes, SC Gómez, V Quezada… - Pharmaceutics, 2022 - mdpi.com
Magnetite nanoparticles (MNPs) have gained significant attention in several applications for
drug delivery. However, there are some issues related to cell penetration, especially in the …

[HTML][HTML] Endosomal escape in magnetic nanostructures: Recent advances and future perspectives

SD Shirsat, PV Londhe, AP Gaikwad, M Rizwan… - Materials Today …, 2024 - Elsevier
Several evolving therapies depend on the delivery of therapeutic cargo into the cytoplasm.
Engineered magnetic nanoparticles (MNPs) have played a pivotal role in advancing and …

Comparison of acetaminophen degradation by laccases immobilized by two different methods via a continuous flow microreactor process scheme

LD Sotelo, DC Sotelo, N Ornelas-Soto, JC Cruz… - Membranes, 2022 - mdpi.com
The presence of micropollutants in wastewater is one of the most significant environmental
challenges. Particularly, pollutants such as pharmaceutical residues present high stability …