Delivery systems for nucleic acids and proteins: Barriers, cell capture pathways and nanocarriers
Gene therapy has been used as a potential approach to address the diagnosis and
treatment of genetic diseases and inherited disorders. In this line, non-viral systems have …
treatment of genetic diseases and inherited disorders. In this line, non-viral systems have …
Tailoring iron oxide nanoparticles for efficient cellular internalization and endosomal escape
L Rueda-Gensini, J Cifuentes, MC Castellanos… - Nanomaterials, 2020 - mdpi.com
Iron oxide nanoparticles (IONs) have been widely explored for biomedical applications due
to their high biocompatibility, surface-coating versatility, and superparamagnetic properties …
to their high biocompatibility, surface-coating versatility, and superparamagnetic properties …
Biomimetic lipopolysaccharide‐free bacterial outer membrane‐functionalized nanoparticles for brain‐targeted drug delivery
H Chen, M Zhou, Y Zeng, T Miao, H Luo… - Advanced …, 2022 - Wiley Online Library
The blood–brain barrier (BBB) severely blocks the intracranial accumulation of most
systemic drugs. Inspired by the contribution of the bacterial outer membrane to Escherichia …
systemic drugs. Inspired by the contribution of the bacterial outer membrane to Escherichia …
Treatment of wastewater, phenols and dyes using novel magnetic torus microreactors and laccase immobilized on magnetite nanoparticles
In this work, the design, manufacture, and testing of three different magnetic microreactors
based on torus geometries (ie, one-loop, two-horizontal-loop, and two-vertical-loop) is …
based on torus geometries (ie, one-loop, two-horizontal-loop, and two-vertical-loop) is …
Efficient CRISPR/Cas9 nickase-mediated genome editing in an in vitro model of mucopolysaccharidosis IVA
AF Leal, CJ Alméciga-Díaz - Gene Therapy, 2023 - nature.com
Abstract Mucopolysaccharidosis IVA (MPS IVA) is a lysosomal storage disorder (LSD)
caused by mutations in gene encoding for GALNS enzyme. Lack of GALNS activity leads to …
caused by mutations in gene encoding for GALNS enzyme. Lack of GALNS activity leads to …
Multifunctional magnetite nanoparticles to enable delivery of siRNA for the potential treatment of Alzheimer's
N Lopez-Barbosa, JG Garcia, J Cifuentes… - Drug Delivery, 2020 - Taylor & Francis
Therapeutic drugs for Alzheimer's disease have been extensively studied due to its
recurrence and abundance among neurodegenerative diseases. It is thought that the …
recurrence and abundance among neurodegenerative diseases. It is thought that the …
The landscape of CRISPR/Cas9 for inborn errors of metabolism
AF Leal, N Fnu, E Benincore-Flórez… - Molecular genetics and …, 2023 - Elsevier
Since its discovery as a genome editing tool, the clustered regularly interspaced short
palindromic repeats and CRISPR-associated protein 9 (CRISPR/Cas9) system has opened …
palindromic repeats and CRISPR-associated protein 9 (CRISPR/Cas9) system has opened …
Microfluidic synthesis and purification of magnetoliposomes for potential applications in the gastrointestinal delivery of difficult-to-transport drugs
Magnetite nanoparticles (MNPs) have gained significant attention in several applications for
drug delivery. However, there are some issues related to cell penetration, especially in the …
drug delivery. However, there are some issues related to cell penetration, especially in the …
[HTML][HTML] Endosomal escape in magnetic nanostructures: Recent advances and future perspectives
SD Shirsat, PV Londhe, AP Gaikwad, M Rizwan… - Materials Today …, 2024 - Elsevier
Several evolving therapies depend on the delivery of therapeutic cargo into the cytoplasm.
Engineered magnetic nanoparticles (MNPs) have played a pivotal role in advancing and …
Engineered magnetic nanoparticles (MNPs) have played a pivotal role in advancing and …
Comparison of acetaminophen degradation by laccases immobilized by two different methods via a continuous flow microreactor process scheme
The presence of micropollutants in wastewater is one of the most significant environmental
challenges. Particularly, pollutants such as pharmaceutical residues present high stability …
challenges. Particularly, pollutants such as pharmaceutical residues present high stability …