What made sesquiterpene lactones reach cancer clinical trials?

A Ghantous, H Gali-Muhtasib, H Vuorela, NA Saliba… - Drug discovery today, 2010 - Elsevier
Sesquiterpene lactones (SLs) are plant-derived compounds often used in traditional
medicine against inflammation and cancer. This review focuses on the chemical and …

Biological activities of sesquiterpene lactones

AK Picman - Biochemical systematics and Ecology, 1986 - Elsevier
Although sesquiterpene lactones are terpenoid compounds characteristic of the Asteraceae
(Compositae) they are also known from other angiosperm families as well as from some …

Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome

C Juliana, T Fernandes-Alnemri, J Wu, P Datta… - Journal of Biological …, 2010 - ASBMB
Activation of the inflammasome generates the pro-inflammatory cytokines interleukin-1β and-
18, which are important mediators of inflammation. Abnormal activation of the inflammasome …

Naturally occurring NF-κB inhibitors

NH Nam - Mini reviews in medicinal chemistry, 2006 - ingentaconnect.com
NF-κB is a ubiquitous and well-characterised protein responsible for the regulation of
complex phenomena, with a pivotal role in controlling cell signalling in the body under …

Perspectives on sesquiterpene lactones in inflammation and cancer

I Merfort - Current drug targets, 2011 - ingentaconnect.com
Sesquiterpene lactones are a large group of secondary plant metabolites mostly known from
the Asteraceae family. They exert a broad variety of different biological activities. This review …

Single components of botanicals and nature-identical compounds as a non-antibiotic strategy to ameliorate health status and improve performance in poultry and pigs

B Rossi, A Toschi, A Piva, E Grilli - Nutrition Research Reviews, 2020 - cambridge.org
In the current post-antibiotic era, botanicals represent one of the most employed nutritional
strategies to sustain antibiotic-free and no-antibiotic-ever production. Botanicals can be …

Inhibition of transcription factor NF-κB by sesquiterpene lactones: a proposed molecular mechanism of action

P Rüngeler, V Castro, G Mora, N Gören… - Bioorganic & medicinal …, 1999 - Elsevier
Many sesquiterpene lactones (SLs) possess considerable anti-inflammatory activity. They
inhibit the transcription factor NF-κB by selectively alkylating its p65 subunit probably by …

Preliminary evaluation of anti-inflammatory and anti-arthritic activity of S. lappa, A. speciosa and A. aspera

AB Gokhale, AS Damre, KR Kulkarni, MN Saraf - Phytomedicine, 2002 - Elsevier
Saussurea lappa, Argyreia speciosa and Achyranthes aspera are well known Indian
medicinal plants used in the indigenous systems of medicine for the treatment of …

Quantitative structure− activity relationship of sesquiterpene lactones as inhibitors of the transcription Factor NF-κB

B Siedle, AJ García-Piñeres, R Murillo… - Journal of medicinal …, 2004 - ACS Publications
Sesquiterpene lactones (SLs) are the active compounds of a variety of tradionally used
medicinal plants from the Asteraceae family. They are known to possess a considerable …

Mechanistic and therapeutic role of NLRP3 inflammasome in the pathogenesis of Alzheimer's disease

D Jha, ENTP Bakker, R Kumar - Journal of neurochemistry, 2024 - Wiley Online Library
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, has emerged
as the most common form of dementia in the elderly. Several pathological hallmarks have …