Modern classification of the family of human small heat shock proteins (the so-called HSPB)
is presented, and the structure and properties of three members of this family are analyzed …

The small heat shock protein Hsp27 or its murine homologue Hsp25 acts as an ATP-
independent chaperone in protein folding, but is also implicated in architecture of the …

Heat shock proteins (Hsp) form the most ancient defense system in all living organisms on
earth. These proteins act as molecular chaperones by helping in the refolding of misfolded …

Stem cells have emerged as promising tools for the treatment of incurable neural and heart
diseases and tissue damage. However, the survival of transplanted stem cells is reported to …

Heat shock proteins (Hsps) are highly conserved and under physiological conditions act as
molecular chaperones and/or have anti-apoptotic activities. Expression in the brain of two …

In the human autoimmune blistering disease pemphigus vulgaris (PV) pathogenic
antibodies bind the desmosomal cadherin desmoglein-3 (dsg3), causing epidermal cell-cell …

Desmosomes are patch-like intercellular adhering junctions (“maculae adherentes”), which,
in concert with the related adherens junctions, provide the mechanical strength to …

Pemphigus vulgaris (PV) is a life-threatening autoimmune blistering skin disease
characterized by detachment of keratinocytes (acantholysis). It has been proposed that PV …

Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of
human cancer and frequently metastasizes to LNs. Identifying metastasis-promoting factors …

The molecular chaperone Hsp27 exists as a distribution of large oligomers that are
disassembled by phosphorylation at Ser-15,-78, and-82. It is controversial whether the …