Obesity II: establishing causal links between chemical exposures and obesity

JJ Heindel, S Howard, K Agay-Shay, JP Arrebola… - Biochemical …, 2022 - Elsevier
Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

Early developmental conditioning of later health and disease: physiology or pathophysiology?

MA Hanson, PD Gluckman - Physiological reviews, 2014 - journals.physiology.org
Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …

Environmental obesogens: mechanisms and controversies

JJ Heindel, B Blumberg - Annual review of pharmacology and …, 2019 - annualreviews.org
Obesity is a worldwide pandemic in adults as well as children and adds greatly to health
care costs through its association with type 2 diabetes, metabolic syndrome, cardiovascular …

Benchmarking organic micropollutants in wastewater, recycled water and drinking water with in vitro bioassays

BI Escher, M Allinson, R Altenburger… - … science & technology, 2014 - ACS Publications
Thousands of organic micropollutants and their transformation products occur in water.
Although often present at low concentrations, individual compounds contribute to mixture …

Endocrine disruptors: from endocrine to metabolic disruption

C Casals-Casas, B Desvergne - Annual review of physiology, 2011 - annualreviews.org
Synthetic chemicals currently used in a variety of industrial and agricultural applications are
leading to widespread contamination of the environment. Even though the intended uses of …

Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review

KA Thayer, JJ Heindel, JR Bucher… - Environmental health …, 2012 - ehp.niehs.nih.gov
Background: There has been increasing interest in the concept that exposures to
environmental chemicals may be contributing factors to the epidemics of diabetes and …

endocrine disrupting chemicals and immune responses: a focus on bisphenol-A and its potential mechanisms

JA Rogers, L Metz, VW Yong - Molecular immunology, 2013 - Elsevier
Endocrine disrupting chemicals (EDCs) have become of concern for a variety f health
issues. Due to their effects on the endocrine system they have been thoroughly examined …

[HTML][HTML] Environmental obesogens and their impact on susceptibility to obesity: new mechanisms and chemicals

RJ Egusquiza, B Blumberg - Endocrinology, 2020 - academic.oup.com
The incidence of obesity has reached an all-time high, and this increase is observed
worldwide. There is a growing need to understand all the factors that contribute to obesity to …

The retinoid X receptors and their ligands

MI Dawson, Z Xia - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2012 - Elsevier
This chapter presents an overview of the current status of studies on the structural and
molecular biology of the retinoid X receptor subtypes α, β, and γ (RXRs, NR2B1–3), their …

Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes

V Delfosse, M Grimaldi, JL Pons… - Proceedings of the …, 2012 - National Acad Sciences
Bisphenol A (BPA) is an industrial compound and a well known endocrine-disrupting
chemical with estrogenic activity. The widespread exposure of individuals to BPA is …