Engineering vascularized organoid-on-a-chip models
VS Shirure, CCW Hughes… - Annual Review of …, 2021 - annualreviews.org
Recreating human organ–level function in vitro is a rapidly evolving field that integrates
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …
[HTML][HTML] Tumor-on-chip modeling of organ-specific cancer and metastasis
Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …
that accurately mimic human oncology–a requirement for the development of more effective …
Microfluidic tissue engineering and bio‐actuation
Bio‐hybrid technologies aim to replicate the unique capabilities of biological systems that
could surpass advanced artificial technologies. Soft bio‐hybrid robots consist of synthetic …
could surpass advanced artificial technologies. Soft bio‐hybrid robots consist of synthetic …
Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases
V Paloschi, M Sabater-Lleal… - Cardiovascular …, 2021 - academic.oup.com
The development of organs-on-chip (OoC) has revolutionized in vitro cell-culture
experiments by allowing a better mimicry of human physiology and pathophysiology that has …
experiments by allowing a better mimicry of human physiology and pathophysiology that has …
Application of CRISPR/Cas9 to human-induced pluripotent stem cells: from gene editing to drug discovery
C De Masi, P Spitalieri, M Murdocca, G Novelli… - Human genomics, 2020 - Springer
Human-induced pluripotent stem cells (hiPSCs) and CRISPR/Cas9 gene editing system
represent two instruments of basic and translational research, which both allow to acquire …
represent two instruments of basic and translational research, which both allow to acquire …
[HTML][HTML] Emerging trends in organ-on-a-chip systems for drug screening
New drug discovery is under growing pressure to satisfy the demand from a wide range of
domains, especially from the pharmaceutical industry and healthcare services. Assessment …
domains, especially from the pharmaceutical industry and healthcare services. Assessment …
Organ-on-a-chip platforms for drug screening and delivery in tumor cells: A systematic review
IM Gonçalves, V Carvalho, RO Rodrigues, D Pinho… - Cancers, 2022 - mdpi.com
Simple Summary Cancer is one of the diseases with a high mortality rate worldwide. Of the
current strategies to study new diagnostic and treating tools, organs-on-chip are quite …
current strategies to study new diagnostic and treating tools, organs-on-chip are quite …
Design and engineering of organ-on-a-chip
S Cho, S Lee, SI Ahn - Biomedical engineering letters, 2023 - Springer
Abstract Organ-on-a-chip (OOC) is an emerging interdisciplinary technology that
reconstitutes the structure, function, and physiology of human tissues as an alternative to …
reconstitutes the structure, function, and physiology of human tissues as an alternative to …
A comprehensive review on 3D tissue models: Biofabrication technologies and preclinical applications
R Xie, V Pal, Y Yu, X Lu, M Gao, S Liang, M Huang… - Biomaterials, 2023 - Elsevier
The limitations of traditional two-dimensional (2D) cultures and animal testing, when it
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …
Scaffold-based 3D cell culture models in cancer research
Abstract Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer
research, offering significant advantages over traditional two-dimensional (2D) cell culture …
research, offering significant advantages over traditional two-dimensional (2D) cell culture …