The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Traditional diagnostic systems went beyond empirical evidence on the structure of mental
health. Consequently, these diagnoses do not depict psychopathology accurately, and their …

The Hierarchical Taxonomy of Psychopathology (HiTOP) is a scientific effort to address
shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary …

Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …

The Hierarchical Taxonomy of Psychopathology (HiTOP) is a quantitative nosological
system that addresses shortcomings of traditional mental disorder diagnoses, including …

Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often
inadequately treated by traditional antidepressants. The modern framework of anhedonia …

We describe evidence for dissociable roles of the medial and lateral orbitofrontal cortex
(OFC) in major depressive disorder (MDD) from structure, functional activation, functional …

Anhedonia, as evidenced by impaired pleasurable response to reward, reduced reward
motivation, and/or deficits in reward-related learning, is a common feature of depression …

Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body …

Importance Anhedonia, a reduced capacity for pleasure, is described for many psychiatric
and neurologic conditions. However, a decade after the Research Domain Criteria launch …