Rheumatoid arthritis: the old issue, the new therapeutic approach

M Babaahmadi, B Tayebi, NM Gholipour… - Stem Cell Research & …, 2023 - Springer
Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease of unknown
etiology. The most common form of this disease is chronic inflammatory arthritis, which …

Comprehensive overview of microRNA function in rheumatoid arthritis

X Peng, Q Wang, W Li, G Ge, J Peng, Y Xu, H Yang… - Bone Research, 2023 - nature.com
MicroRNAs (miRNAs), a class of endogenous single-stranded short noncoding RNAs, have
emerged as vital epigenetic regulators of both pathological and physiological processes in …

Synovial fibroblasts as potential drug targets in rheumatoid arthritis, where do we stand and where shall we go?

T Németh, G Nagy, T Pap - Annals of the Rheumatic Diseases, 2022 - ard.bmj.com
Fibroblast-like synoviocytes or synovial fibroblasts (FLS) are important cellular components
of the inner layer of the joint capsule, referred to as the synovial membrane. They can be …

Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis

S Ahmed, CB Mahony, A Torres, J Murillo-Saich… - Arthritis Research & …, 2023 - Springer
Background Synovial fibroblasts in rheumatoid arthritis (RAFLS) exhibit a pathological
aberration of glycolysis and glutaminolysis. Henceforth, we aimed to investigate if dual …

Analysis and experimental validation of rheumatoid arthritis innate immunity gene CYFIP2 and pan-cancer

ZY Zhao, SJ He, XC Yu, XF Lai, S Tang… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic, heterogeneous autoimmune disease. Its high
disability rate has a serious impact on society and individuals, but there is still a lack of …

The synovial fluid fibroblast-like synoviocyte: A long-neglected piece in the puzzle of rheumatoid arthritis pathogenesis

DE Mahmoud, W Kaabachi, N Sassi… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic autoimmune disease during which fibroblast-like
synoviocytes (FLS) contribute to both joint inflammation and destruction. FLS represent the …

Epigenetic regulation in the pathogenesis of rheumatoid arthritis

C Yang, D Li, D Teng, Y Zhou, L Zhang… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease. The etiology of RA remains
undetermined and the pathogenesis is complex. There remains a paucity of ideal …

Therapeutic antibodies in medicine

P Sharma, RV Joshi, R Pritchard, K Xu, MA Eicher - Molecules, 2023 - mdpi.com
Antibody engineering has developed into a wide-reaching field, impacting a multitude of
industries, most notably healthcare and diagnostics. The seminal work on developing the …

Rheumatoid arthritis molecular targets and their importance to flavonoid‐based therapy

AT Rufino, M Freitas, C Proença… - Medicinal Research …, 2024 - Wiley Online Library
Rheumatoid arthritis (RA) is a progressive, chronic, autoimmune, inflammatory, and systemic
condition that primarily affects the synovial joints and adjacent tissues, including bone …

Cadherin signaling in cancer and autoimmune diseases

M Sisto, D Ribatti, S Lisi - International Journal of Molecular Sciences, 2021 - mdpi.com
Cadherins mediate cell–cell adhesion through a dynamic process that is strongly dependent
on the cellular context and signaling. Cadherin regulation reflects the interplay between …