Jingmenviruses: Ubiquitous, understudied, segmented flavi-like viruses

AMG Colmant, RN Charrel, B Coutard - Frontiers in microbiology, 2022 - frontiersin.org
Jingmenviruses are a group of viruses identified recently, in 2014, and currently classified by
the International Committee on Taxonomy of Viruses as unclassified Flaviviridae. These …

The Japanese encephalitis antigenic complex viruses: from structure to immunity

B Khare, RJ Kuhn - Viruses, 2022 - mdpi.com
In the last three decades, several flaviviruses of concern that belong to different antigenic
groups have expanded geographically. This has resulted in the presence of often more than …

[HTML][HTML] The epitope arrangement on flavivirus particles contributes to Mab C10's extraordinary neutralization breadth across Zika and dengue viruses

A Sharma, X Zhang, W Dejnirattisai, X Dai, D Gong… - Cell, 2021 - cell.com
The human monoclonal antibody C10 exhibits extraordinary cross-reactivity, potently
neutralizing Zika virus (ZIKV) and the four serotypes of dengue virus (DENV1–DENV4). Here …

Molecular organisation of tick-borne encephalitis virus

LIA Pulkkinen, SV Barrass, A Domanska, AK Överby… - Viruses, 2022 - mdpi.com
Tick-borne encephalitis virus (TBEV) is a pathogenic, enveloped, positive-stranded RNA
virus in the family Flaviviridae. Structural studies of flavivirus virions have primarily focused …

Cryo-EM structures of human hepatitis B and woodchuck hepatitis virus small spherical subviral particles

H Liu, X Hong, J Xi, S Menne, J Hu, JCY Wang - Science Advances, 2022 - science.org
The loss of detectable hepatitis B surface antigen (HBsAg) is considered a functional cure in
chronic hepatitis B. Naturally, HBsAg can be incorporated into the virion envelope or …

Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery

MC Vaney, M Dellarole, S Duquerroy, I Medits… - Nature …, 2022 - nature.com
The flavivirus envelope glycoproteins prM and E drive the assembly of icosahedral, spiky
immature particles that bud across the membrane of the endoplasmic reticulum. Maturation …

A chimeric vaccine derived from Australian genotype IV Japanese encephalitis virus protects mice from lethal challenge

JJ Harrison, W Nguyen, MS Morgan, B Tang… - npj Vaccines, 2024 - nature.com
In 2022, a genotype IV (GIV) strain of Japanese encephalitis virus (JEV) caused an
unprecedented and widespread outbreak of disease in pigs and humans in Australia. As no …

Structure of Usutu virus SAAR-1776 displays fusion loop asymmetry

B Khare, T Klose, Q Fang… - Proceedings of the …, 2021 - National Acad Sciences
Usutu virus (USUV) is an emerging arbovirus in Europe that has been increasingly identified
in asymptomatic humans and donated blood samples and is a cause of increased incidents …

The chimeric Binjari-Zika vaccine provides long-term protection against ZIKA virus challenge

JE Hazlewood, B Tang, K Yan, DJ Rawle, JJ Harrison… - Vaccines, 2022 - mdpi.com
We recently developed a chimeric flavivirus vaccine technology based on the novel insect-
specific Binjari virus (BinJV) and used this to generate a chimeric ZIKV vaccine (BinJ/ZIKA …

Chimeric vaccines based on novel insect-specific flaviviruses

JJ Harrison, J Hobson-Peters, H Bielefeldt-Ohmann… - Vaccines, 2021 - mdpi.com
Vector-borne flaviviruses are responsible for nearly half a billion human infections
worldwide each year, resulting in millions of cases of debilitating and severe diseases and …