The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
F Lyko - Nature Reviews Genetics, 2018 - nature.com
The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying
enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …
enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …
Principles of DNA methylation and their implications for biology and medicine
DNA methylation represents an annotation system for marking the genetic text, thus
providing instruction as to how and when to read the information and control transcription …
providing instruction as to how and when to read the information and control transcription …
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states
Single-cell RNA sequencing has revealed extensive transcriptional cell state diversity in
cancer, often observed independently of genetic heterogeneity, raising the central question …
cancer, often observed independently of genetic heterogeneity, raising the central question …
TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
DNA methylation clocks in aging: categories, causes, and consequences
Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …
thought to promote diseases of aging, such as cancer. Recent studies have identified …
The interplay of epigenetic marks during stem cell differentiation and development
Y Atlasi, HG Stunnenberg - Nature Reviews Genetics, 2017 - nature.com
Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly
reshaped during early development and differentiation. Epigenetic modification of chromatin …
reshaped during early development and differentiation. Epigenetic modification of chromatin …
Role of mammalian DNA methyltransferases in development
DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian
development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the …
development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the …
The DNA methylation landscape in cancer
As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …
plays an essential role in normal development and cellular biology. Global alterations to the …
Function and information content of DNA methylation
D Schübeler - Nature, 2015 - nature.com
Cytosine methylation is a DNA modification generally associated with transcriptional
silencing. Factors that regulate methylation have been linked to human disease, yet how …
silencing. Factors that regulate methylation have been linked to human disease, yet how …
Active turnover of DNA methylation during cell fate decisions
DNA methylation is a key layer of epigenetic regulation. The deposition of methylation marks
relies on the catalytic activity of DNA methyltransferases (DNMTs), and their active removal …
relies on the catalytic activity of DNA methyltransferases (DNMTs), and their active removal …