Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members)
has been implicated in cancer and other human diseases. However, in contrast to the direct …

Highly ordered organisation of striated muscle is the prerequisite for the fast and
unidirectional development of force and motion during heart and skeletal muscle …

Cardiac muscle cells are equipped with specialized biochemical machineries for the rapid
generation of force and movement central to the work generated by the heart. During each …

The sarcomere is the basic unit of the myofibrils, which mediate skeletal and cardiac Muscle
contraction. Two transverse structures, the Z-disc and the M-band, anchor the thin (actin and …

Centronuclear myopathies (CNMs) are characterized by muscle weakness and increased
numbers of central nuclei within myofibers. X-linked myotubular myopathy, the most …

In C. elegans, mutants that are defective in muscle function and/or structure are easy to
detect and analyze since: 1) body wall muscle is essential for locomotion, and 2) muscle …

Recent interest has focused on the importance of the nucleus and associated
nucleoskeleton in regulating changes in cardiac gene expression in response to …

In striated muscle sarcomeres, the contractile actin and myosin filaments are organised by a
subset of specialised cytoskeletal proteins, the sarcomeric cytoskeleton. They include α …

We review some of the problems in determining how myofibrils may be assembled and just
as importantly how this contractile structure may be renewed by sarcomeric proteins moving …