Highlights•Promiscuous regulatory activity (crosstalk) reveals novel regulatory interactions to
selection.•Crosstalk creates opportunities for genetic innovation that can facilitate …

Evolutionary adaptation often occurs by the fixation of beneficial mutations. This mode of
adaptation can be characterized quantitatively by a spectrum of adaptive substitutions, ie, a …

The mapping from genotype to phenotype to fitness typically involves multiple nonlinearities
that can transform the effects of mutations. For example, mutations may contribute additively …

Biomorphs, Richard Dawkins's iconic model of morphological evolution, are traditionally
used to demonstrate the power of natural selection to generate biological order from random …

An important question in evolutionary biology is whether (and in what ways) genotype–
phenotype (GP) map biases can influence evolutionary trajectories. Untangling the relative …

The idea that adaptive change is subject to biases in variation by a" first come, first served"
dynamic is not part of classic evolutionary reasoning. Yet, predictable effects of biases in the …

An important question in evolutionary biology is whether and in what ways genotype-
phenotype (GP) map biases can influence evolutionary trajectories. Untangling the relative …

The ability to generate rapid phenotypic diversification and innovation is frequently the
deciding factor for the survival or extinction of a population. From metazoa to microbes, gene …

The mapping from genotype to phenotype to fitness typically involves multiple nonlinearities
that can transform the effects of mutations. For example, mutations may contribute additively …

The mapping from genotype to phenotype to fitness typically involves multiple nonlinearities
that can transform the 9 individual and combined effects of mutations. For example …