Naive T cells are actively maintained in a quiescent state that promotes their survival and
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …

The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of
rapamycin) forms the distinct protein complexes mTORC1 and mTORC2 and integrates …

The interplay between effector T cells and regulatory T cells (Treg cells) is crucial for
adaptive immunity, but how Treg cells control diverse effector responses is elusive. We …

Tissue-resident immune cells must balance survival in peripheral tissues with the capacity to
respond rapidly upon infection or tissue damage, and in turn couple these responses with …

The mTOR pathway has a central role in the regulation of cell metabolism, growth and
proliferation. Studies involving selective gene targeting of mTOR complexes (mTORC1 and …

Activated lymphocytes engage in robust growth and rapid proliferation. To achieve this, they
tend to adopt a form of glucose metabolism termed aerobic glycolysis. This type of …

Mammalian/mechanistic target of rapamycin (mTOR) is emerging as an important integrator
of environmental cues critical for the regulation of T cell activation, differentiation, and …

As treatment of the early, inflammatory phase of sepsis improves, post-sepsis
immunosuppression and secondary infection have increased in importance. How early …

Cellular metabolism and signaling pathways are key regulators to determine conventional T
cell fate and function, but little is understood about the role of cell metabolism for natural …

T follicular helper (Tfh) cells play critical roles for germinal center responses and effective
humoral immunity. We report here that mTOR in CD4 T cells is essential for Tfh …