Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

COVID-19 convalescent plasma and clinical trials: understanding conflicting outcomes

D Focosi, M Franchini, L Pirofski… - Clinical microbiology …, 2022 - Am Soc Microbiol
Convalescent plasma (CP) recurs as a frontline treatment in epidemics because it is
available as soon as there are survivors. The COVID-19 pandemic represented the first …

An overview on the treatments and prevention against COVID-19

Y Panahi, AM Gorabi, S Talaei, F Beiraghdar… - Virology Journal, 2023 - Springer
Background The coronavirus disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to plague the world. While …

[HTML][HTML] Rates among hospitalized patients with COVID-19 treated with convalescent plasma: a systematic review and meta-analysis

JW Senefeld, EK Gorman, PW Johnson, ME Moir… - … : Innovations, Quality & …, 2023 - Elsevier
Objective To examine the association of COVID-19 convalescent plasma transfusion with
mortality and the differences between subgroups in hospitalized patients with COVID-19 …

Convalescent plasma therapy in COVID-19: Unravelling the data using the principles of antibody therapy

A Casadevall, MJ Joyner, LA Pirofski… - Expert review of …, 2023 - Taylor & Francis
Introduction When the COVID-19 pandemic struck no specific therapies were available and
many turned to COVID-19 convalescent plasma (CCP), a form of antibody therapy. The …

Development and validation of a treatment benefit index to identify hospitalized patients with COVID-19 who may benefit from convalescent plasma

H Park, T Tarpey, M Liu, K Goldfeld, Y Wu… - JAMA network …, 2022 - jamanetwork.com
Importance Identifying which patients with COVID-19 are likely to benefit from COVID-19
convalescent plasma (CCP) treatment may have a large public health impact. Objective To …

A comprehensive review on the efficacy of several pharmacologic agents for the treatment of COVID-19

F Haddad, G Dokmak, R Karaman - Life, 2022 - mdpi.com
Simple Summary Treatments for coronavirus disease-2019 (COVID-19) have utilized a
variety of medications, including antivirals, immunomodulators, and other therapeutics such …

The efficiency of convalescent plasma in COVID-19 patients: A systematic review and meta-analysis of randomized controlled clinical trials

Z Qian, Z Zhang, H Ma, S Shao, H Kang… - Frontiers in …, 2022 - frontiersin.org
The objective of this study was to assess whether convalescent plasma therapy could offer
survival advantages for patients with novel coronavirus disease 2019 (COVID-19). An …

Association between COVID-19 convalescent plasma antibody levels and COVID-19 outcomes stratified by clinical status at presentation

H Park, C Yu, L Pirofski, H Yoon, D Wu, Y Li… - BMC infectious …, 2024 - Springer
Background There is a need to understand the relationship between COVID-19
Convalescent Plasma (CCP) anti-SARS-CoV-2 IgG levels and clinical outcomes to optimize …

[HTML][HTML] Clinical research and drug regulation in the challenging times of individualized therapies: A pivotal role of Clinical Pharmacology

A Gómez-Outes, A Sancho-López, AJC Sansuan… - Pharmacological …, 2024 - Elsevier
Since the 1980s, medical specialists in Clinical Pharmacology have been playing a crucial
role in the development of drug regulation in Spain. In this article we report on the activities …