The aversion of hydrophobic solutes for water drives diverse interactions and assemblies
across materials science, biology, and beyond. Here, we review the theoretical …

Macroscopic characterizations of hydrophobicity (eg, contact angle measurements) do not
extend to the surfaces of proteins and nanoparticles. Molecular measures of hydrophobicity …

Hydrophobicity is often characterized macroscopically by the droplet contact angle.
Molecular signatures of hydrophobicity have, however, remained elusive. Successful …

Formation of biomolecular condensates through liquid-liquid phase separation (LLPS) has
emerged as a pervasive principle in cell biology, allowing compartmentalization and …

We use molecular dynamics simulations of the SPC-E model of liquid water to derive
probability distributions for water density fluctuations in probe volumes of different shapes …

Water near extended hydrophobic surfaces is like that at a liquid–vapor interface, where
fluctuations in water density are substantially enhanced compared to those in bulk water …

Approaches to quantify wetting at the macroscale do not translate to the nanoscale,
highlighting the need for new methods for characterizing hydrophobicity at the small scale …

While individual water molecules adsorb strongly on a talc surface (hydrophilic behavior), a
droplet of water beads up on the same surface (hydrophobic behavior). To rationalize this …

Although it is now relatively well understood how sequence defines and impacts global
protein stability in specific structural contexts, the question of how sequence modulates the …

Cosolvents modulate aqueous solubility, hydrophobic interactions, and the stability and
function of most proteins in the living cell. Our molecular-level understanding of cosolvent …