CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate
CD36 is a type 2 cell surface scavenger receptor widely expressed in many immune and
non-immune cells. It functions as both a signaling receptor responding to DAMPs and …
non-immune cells. It functions as both a signaling receptor responding to DAMPs and …
Emerging roles of vascular endothelium in metabolic homeostasis
X Pi, L Xie, C Patterson - Circulation Research, 2018 - Am Heart Assoc
Our understanding of the role of the vascular endothelium has evolved over the past 2
decades, with the recognition that it is a dynamically regulated organ and that it plays a …
decades, with the recognition that it is a dynamically regulated organ and that it plays a …
Targeting metastasis-initiating cells through the fatty acid receptor CD36
G Pascual, A Avgustinova, S Mejetta, M Martín… - Nature, 2017 - nature.com
The fact that the identity of the cells that initiate metastasis in most human cancers is
unknown hampers the development of antimetastatic therapies. Here we describe a …
unknown hampers the development of antimetastatic therapies. Here we describe a …
Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes
Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and
ATP synthesis but also cause serious stress to various tissues, contributing to the …
ATP synthesis but also cause serious stress to various tissues, contributing to the …
Hepatocyte-specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice
CG Wilson, JL Tran, DM Erion, NB Vera… - …, 2016 - academic.oup.com
CD36/FAT (fatty acid translocase) is associated with human and murine nonalcoholic fatty
liver disease, but it has been unclear whether it is simply a marker or whether it directly …
liver disease, but it has been unclear whether it is simply a marker or whether it directly …
Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
KH Kim, YT Jeong, H Oh, SH Kim, JM Cho, YN Kim… - Nature medicine, 2013 - nature.com
Despite growing interest and a recent surge in papers, the role of autophagy in glucose and
lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of …
lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of …
International society of sports nutrition position stand: Nutritional concerns of the female athlete
Based on a comprehensive review and critical analysis of the literature regarding the
nutritional concerns of female athletes, conducted by experts in the field and selected …
nutritional concerns of female athletes, conducted by experts in the field and selected …
Modulation of endothelium function by fatty acids
R Mallick, AK Duttaroy - Molecular and cellular biochemistry, 2022 - Springer
The endothelium acts as the barrier that prevents circulating lipids such as lipoproteins and
fatty acids into the arterial wall; it also regulates normal functioning in the circulatory system …
fatty acids into the arterial wall; it also regulates normal functioning in the circulatory system …
Pathogenesis of insulin resistance in skeletal muscle
MA Abdul-Ghani, RA DeFronzo - BioMed Research …, 2010 - Wiley Online Library
Insulin resistance in skeletal muscle is manifested by decreased insulin‐stimulated glucose
uptake and results from impaired insulin signaling and multiple post‐receptor intracellular …
uptake and results from impaired insulin signaling and multiple post‐receptor intracellular …
[HTML][HTML] Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
Previous studies have suggested that insulin resistance develops secondary to diminished
fat oxidation and resultant accumulation of cytosolic lipid molecules that impair insulin …
fat oxidation and resultant accumulation of cytosolic lipid molecules that impair insulin …