CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate

Y Chen, J Zhang, W Cui, RL Silverstein - Journal of Experimental …, 2022 - rupress.org
CD36 is a type 2 cell surface scavenger receptor widely expressed in many immune and
non-immune cells. It functions as both a signaling receptor responding to DAMPs and …

Emerging roles of vascular endothelium in metabolic homeostasis

X Pi, L Xie, C Patterson - Circulation Research, 2018 - Am Heart Assoc
Our understanding of the role of the vascular endothelium has evolved over the past 2
decades, with the recognition that it is a dynamically regulated organ and that it plays a …

Targeting metastasis-initiating cells through the fatty acid receptor CD36

G Pascual, A Avgustinova, S Mejetta, M Martín… - Nature, 2017 - nature.com
The fact that the identity of the cells that initiate metastasis in most human cancers is
unknown hampers the development of antimetastatic therapies. Here we describe a …

Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes

LD Ly, S Xu, SK Choi, CM Ha, T Thoudam… - … & molecular medicine, 2017 - nature.com
Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and
ATP synthesis but also cause serious stress to various tissues, contributing to the …

Hepatocyte-specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice

CG Wilson, JL Tran, DM Erion, NB Vera… - …, 2016 - academic.oup.com
CD36/FAT (fatty acid translocase) is associated with human and murine nonalcoholic fatty
liver disease, but it has been unclear whether it is simply a marker or whether it directly …

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

KH Kim, YT Jeong, H Oh, SH Kim, JM Cho, YN Kim… - Nature medicine, 2013 - nature.com
Despite growing interest and a recent surge in papers, the role of autophagy in glucose and
lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of …

International society of sports nutrition position stand: Nutritional concerns of the female athlete

ST Sims, CM Kerksick, AE Smith-Ryan… - Journal of the …, 2023 - Taylor & Francis
Based on a comprehensive review and critical analysis of the literature regarding the
nutritional concerns of female athletes, conducted by experts in the field and selected …

Modulation of endothelium function by fatty acids

R Mallick, AK Duttaroy - Molecular and cellular biochemistry, 2022 - Springer
The endothelium acts as the barrier that prevents circulating lipids such as lipoproteins and
fatty acids into the arterial wall; it also regulates normal functioning in the circulatory system …

Pathogenesis of insulin resistance in skeletal muscle

MA Abdul-Ghani, RA DeFronzo - BioMed Research …, 2010 - Wiley Online Library
Insulin resistance in skeletal muscle is manifested by decreased insulin‐stimulated glucose
uptake and results from impaired insulin signaling and multiple post‐receptor intracellular …

[HTML][HTML] Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance

TR Koves, JR Ussher, RC Noland, D Slentz… - Cell metabolism, 2008 - cell.com
Previous studies have suggested that insulin resistance develops secondary to diminished
fat oxidation and resultant accumulation of cytosolic lipid molecules that impair insulin …