CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease

JFC Glatz, LC Heather… - Physiological reviews, 2024 - journals.physiology.org
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …

[HTML][HTML] Hypertension and cardiomyopathy associated with chronic kidney disease: epidemiology, pathogenesis and treatment considerations

JP Law, L Pickup, D Pavlovic, JN Townend… - Journal of Human …, 2023 - nature.com
Chronic kidney disease (CKD) is a complex condition with a prevalence of 10–15%
worldwide. An inverse-graded relationship exists between cardiovascular events and …

Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images

B Zhao, T Li, Z Fan, Y Yang, J Shu, X Yang, X Wang… - Science, 2023 - science.org
Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …

[HTML][HTML] METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner

R Zhang, Y Qu, Z Ji, C Hao, Y Su, Y Yao, W Zuo… - Cellular & molecular …, 2022 - Springer
Background METTL3 is the core catalytic enzyme in m6A and is involved in a variety of
cardiovascular diseases. However, whether and how METTL3 plays a role during …

Catecholamine physiology and its implications in patients with COVID-19

S Gubbi, MA Nazari, D Taieb… - The Lancet Diabetes & …, 2020 - thelancet.com
The risk factors for severe COVID-19 are diverse, yet closely resemble the clinical
manifestations of catecholamine excess states (eg, hypertension, cardiovascular disease …

Influence of cardiometabolic comorbidities on myocardial function, infarction, and cardioprotection: Role of cardiac redox signaling

I Andreadou, A Daiber, GF Baxter, MF Brizzi… - Free Radical Biology …, 2021 - Elsevier
The morbidity and mortality from cardiovascular diseases (CVD) remain high. Metabolic
diseases such as obesity, hyperlipidemia, diabetes mellitus (DM), non-alcoholic fatty liver …

[HTML][HTML] RhoA: a dubious molecule in cardiac pathophysiology

LS Kilian, J Voran, D Frank, AY Rangrez - Journal of biomedical science, 2021 - Springer
The Ras homolog gene family member A (RhoA) is the founding member of Rho GTPase
superfamily originally studied in cancer cells where it was found to stimulate cell cycle …

[HTML][HTML] Emerging roles of the RNA modifications N6-methyladenosine and adenosine-to-inosine in cardiovascular diseases

V Sikorski, A Vento, E Kankuri - Molecular Therapy-Nucleic Acids, 2022 - cell.com
Cardiovascular diseases lead the mortality and morbidity disease metrics worldwide. A
multitude of chemical base modifications in ribonucleic acids (RNAs) have been linked with …

Myocardial strain in hypertension: a meta-analysis of two-dimensional speckle tracking echocardiographic studies

M Tadic, C Sala, S Carugo, G Mancia… - Journal of …, 2021 - journals.lww.com
Aim: Available evidence on systolic dysfunction in systemic hypertension, as assessed by
left ventricular (LV) mechanics, is still based on single studies. Thus, we performed a …

Screening for dilated cardiomyopathy in at-risk first-degree relatives

H Ni, E Jordan, DD Kinnamon, J Cao, GJ Haas… - Journal of the American …, 2023 - jacc.org
Background Cardiovascular screening is recommended for first-degree relatives (FDRs) of
patients with dilated cardiomyopathy (DCM), but the yield of FDR screening is uncertain for …