CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease
JFC Glatz, LC Heather… - Physiological reviews, 2024 - journals.physiology.org
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …
[HTML][HTML] Hypertension and cardiomyopathy associated with chronic kidney disease: epidemiology, pathogenesis and treatment considerations
Chronic kidney disease (CKD) is a complex condition with a prevalence of 10–15%
worldwide. An inverse-graded relationship exists between cardiovascular events and …
worldwide. An inverse-graded relationship exists between cardiovascular events and …
Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images
Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …
[HTML][HTML] METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner
R Zhang, Y Qu, Z Ji, C Hao, Y Su, Y Yao, W Zuo… - Cellular & molecular …, 2022 - Springer
Background METTL3 is the core catalytic enzyme in m6A and is involved in a variety of
cardiovascular diseases. However, whether and how METTL3 plays a role during …
cardiovascular diseases. However, whether and how METTL3 plays a role during …
Catecholamine physiology and its implications in patients with COVID-19
S Gubbi, MA Nazari, D Taieb… - The Lancet Diabetes & …, 2020 - thelancet.com
The risk factors for severe COVID-19 are diverse, yet closely resemble the clinical
manifestations of catecholamine excess states (eg, hypertension, cardiovascular disease …
manifestations of catecholamine excess states (eg, hypertension, cardiovascular disease …
Influence of cardiometabolic comorbidities on myocardial function, infarction, and cardioprotection: Role of cardiac redox signaling
The morbidity and mortality from cardiovascular diseases (CVD) remain high. Metabolic
diseases such as obesity, hyperlipidemia, diabetes mellitus (DM), non-alcoholic fatty liver …
diseases such as obesity, hyperlipidemia, diabetes mellitus (DM), non-alcoholic fatty liver …
[HTML][HTML] RhoA: a dubious molecule in cardiac pathophysiology
The Ras homolog gene family member A (RhoA) is the founding member of Rho GTPase
superfamily originally studied in cancer cells where it was found to stimulate cell cycle …
superfamily originally studied in cancer cells where it was found to stimulate cell cycle …
[HTML][HTML] Emerging roles of the RNA modifications N6-methyladenosine and adenosine-to-inosine in cardiovascular diseases
V Sikorski, A Vento, E Kankuri - Molecular Therapy-Nucleic Acids, 2022 - cell.com
Cardiovascular diseases lead the mortality and morbidity disease metrics worldwide. A
multitude of chemical base modifications in ribonucleic acids (RNAs) have been linked with …
multitude of chemical base modifications in ribonucleic acids (RNAs) have been linked with …
Myocardial strain in hypertension: a meta-analysis of two-dimensional speckle tracking echocardiographic studies
M Tadic, C Sala, S Carugo, G Mancia… - Journal of …, 2021 - journals.lww.com
Aim: Available evidence on systolic dysfunction in systemic hypertension, as assessed by
left ventricular (LV) mechanics, is still based on single studies. Thus, we performed a …
left ventricular (LV) mechanics, is still based on single studies. Thus, we performed a …
Screening for dilated cardiomyopathy in at-risk first-degree relatives
H Ni, E Jordan, DD Kinnamon, J Cao, GJ Haas… - Journal of the American …, 2023 - jacc.org
Background Cardiovascular screening is recommended for first-degree relatives (FDRs) of
patients with dilated cardiomyopathy (DCM), but the yield of FDR screening is uncertain for …
patients with dilated cardiomyopathy (DCM), but the yield of FDR screening is uncertain for …