Prediction of pKa values for neutral and basic drugs based on hybrid artificial intelligence methods

M Li, H Zhang, B Chen, Y Wu, L Guan - Scientific reports, 2018 - nature.com
The pKa value of drugs is an important parameter in drug design and pharmacology. In this
paper, an improved particle swarm optimization (PSO) algorithm was proposed based on …

A novel hybrid machine learning model for predicting rate constants of the reactions between alkane and CH3 radical

J Yu, D Shan, H Song, M Yang - Fuel, 2022 - Elsevier
The rate constants of H-abstraction reactions of alkanes by free radicals are crucial for
optimizing combustion reaction network, improving combustion efficiency and designing …

Chi-MIC-share: A new feature selection algorithm for quantitative structure–activity relationship models

Y Li, Z Dai, D Cao, F Luo, Y Chen, Z Yuan - RSC advances, 2020 - pubs.rsc.org
Quantitative structure–activity relationship models are used in toxicology to predict the
effects of organic compounds on aquatic organisms. Common filter feature selection …

Correlation Study for The Determination of pKa of A Number of Schiff Bases Derived from N-Formyl Pyridine using Quantum Mechanical Methods

RTG Al-Abady, F Altaie, E Al-Hyali - Egyptian Journal of Chemistry, 2021 - journals.ekb.eg
Statistical analysis employing multiparametric regression analysis was used to correlate the
pKa values of 16 substituted Schiff bases (imines) derived from heterogeneous carbonyl …