CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond

AF Russo, DL Hay - Physiological reviews, 2023 - journals.physiology.org
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …

COVID‐19 is a real headache!

H Bolay, A Gül, B Baykan - … : The Journal of Head and Face …, 2020 - Wiley Online Library
After the emergence of a novel coronavirus named SARS‐CoV‐2, coronavirus disease 2019
(COVID‐19) was initially characterized by fever, sore throat, cough, and dyspnea, mainly …

Migraine: from pathophysiology to treatment

F Puledda, EM Silva, K Suwanlaong, PJ Goadsby - Journal of Neurology, 2023 - Springer
Migraine is an extremely disabling, common neurological disorder characterized by a
complex neurobiology, involving a series of central and peripheral nervous system areas …

Migraine and the trigeminovascular system—40 years and counting

M Ashina, JM Hansen, TP Do, A Melo-Carrillo… - The Lancet …, 2019 - thelancet.com
The underlying causes of migraine headache remained enigmatic for most of the 20th
century. In 1979, The Lancet published a novel hypothesis proposing an integral role for the …

Pathophysiology of migraine: a disorder of sensory processing

PJ Goadsby, PR Holland… - Physiological …, 2017 - journals.physiology.org
Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Migraine and neuroinflammation: the inflammasome perspective

O Kursun, M Yemisci… - The journal of headache …, 2021 - Springer
Background Neuroinflammation has an important role in the pathophysiology of migraine,
which is a complex neuro-glio-vascular disorder. The main aim of this review is to highlight …

Light in diagnosis, therapy and surgery

SH Yun, SJJ Kwok - Nature biomedical engineering, 2017 - nature.com
Light and optical techniques have made profound impacts on modern medicine, with
numerous lasers and optical devices currently being used in clinical practice to assess …

Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine

L Yang, M Xu, SA Bhuiyan, J Li, J Zhao, RJ Cohrs… - Neuron, 2022 - cell.com
Sensitization of trigeminal ganglion neurons contributes to primary headache disorders such
as migraine, but the specific neuronal and non-neuronal trigeminal subtypes that are …

Mechanisms of migraine as a chronic evolutive condition

AP Andreou, L Edvinsson - The journal of headache and pain, 2019 - Springer
Understanding the mechanisms of migraine remains challenging as migraine is not a static
disorder, and even in its episodic form migraine remains an “evolutive” chronic condition …

Does inflammation have a role in migraine?

L Edvinsson, KA Haanes, K Warfvinge - Nature Reviews Neurology, 2019 - nature.com
Migraine is a prevalent disorder, affecting 15.1% of the world's population. In most cases, the
migraine attacks are sporadic; however, some individuals experience a gradual increase in …