Formation of the human heart involves complex biological signals, interactions, specification
of myocardial progenitor cells, and heart tube looping. To facilitate survival in the hypoxemic …

WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Organoids capable of forming tissue-like structures have transformed our ability to model
human development and disease. With the notable exception of the human heart, lineage …

Human pluripotent stem cells (hPSCs) offer the potential to generate large numbers of
functional cardiomyocytes from clonal and patient-specific cell sources. Here we show that …

Efficient differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells
(iPSCs) to a variety of lineages requires step-wise approaches replicating the key …

The functional heart is comprised of distinct mesoderm-derived lineages including
cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse …

Attempts to repair myocardial infarcts by transplanting cardiomyocytes or skeletal myoblasts
have failed to reconstitute healthy myocardium and coronary vessels integrated structurally …

Dickkopf (Dkk) genes comprise an evolutionary conserved small gene family of four
members (Dkk1-4) and a unique Dkk3-related gene, Dkkl1 (soggy). They encode secreted …

The global gene expression profiles for 67 human lung tumors representing 56 patients
were examined by using 24,000-element cDNA microarrays. Subdivision of the tumors …

How animals establish and pattern the primary body axis is one of the most fundamental
problems in biology. Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) …