Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues

RHB Benedict, MP Amato, J DeLuca… - The Lancet …, 2020 - thelancet.com
Multiple sclerosis is a chronic, demyelinating disease of the CNS. Cognitive impairment is a
sometimes neglected, yet common, sign and symptom with a profound effect on instrumental …

Treatment optimization in multiple sclerosis: Canadian MS working group recommendations

MS Freedman, V Devonshire, P Duquette… - Canadian Journal of …, 2020 - cambridge.org
The Canadian Multiple Sclerosis Working Group has updated its treatment optimization
recommendations (TORs) on the optimal use of disease-modifying therapies for patients …

Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial …

R Kapoor, PR Ho, N Campbell, I Chang… - The Lancet …, 2018 - thelancet.com
Background Although several disease-modifying treatments are available for relapsing
multiple sclerosis, treatment effects have been more modest in progressive multiple …

Wearable haptics and immersive virtual reality rehabilitation training in children with neuromotor impairments

I Bortone, D Leonardis, N Mastronicola… - … on Neural Systems …, 2018 - ieeexplore.ieee.org
The past decade has seen the emergence of rehabilitation treatments using virtual reality
(VR) environments although translation into clinical practice has been limited so far. In this …

Immersive virtual environments and wearable haptic devices in rehabilitation of children with neuromotor impairments: a single-blind randomized controlled crossover …

I Bortone, M Barsotti, D Leonardis, A Crecchi… - … of neuroengineering and …, 2020 - Springer
Background The past decade has seen the emergence of rehabilitation treatments using
virtual reality. One of the advantages in using this technology is the potential to create …

Diagnosis and management of progressive multiple sclerosis

G Macaron, D Ontaneda - Biomedicines, 2019 - mdpi.com
Multiple sclerosis is a chronic autoimmune disease of the central nervous system that results
in varying degrees of disability. Progressive multiple sclerosis, characterized by a steady …

Effects of home-based virtual reality telerehabilitation system in people with multiple sclerosis: A randomized controlled trial

C Pagliari, S Di Tella, J Jonsdottir… - Journal of …, 2024 - journals.sagepub.com
Background and objective Multiple sclerosis is an inflammatory and neurodegenerative
disorder of the central nervous system that can lead to severe motor disability. The aim of …

Evaluation of multiple sclerosis disability outcome measures using pooled clinical trial data

MD Goldman, NG LaRocca, RA Rudick, LD Hudson… - Neurology, 2019 - AAN Enterprises
Objective We report analyses of a pooled database by the Multiple Sclerosis Outcome
Assessments Consortium to evaluate 4 proposed components of a multidimensional test …

The association of fatigue, pain, depression and anxiety with work and activity impairment in immune mediated inflammatory diseases

MW Enns, CN Bernstein, K Kroeker, L Graff, JR Walker… - PloS one, 2018 - journals.plos.org
Impairment in work function is a frequent outcome in patients with chronic conditions such as
immune-mediated inflammatory diseases (IMID), depression and anxiety disorders. The …

[HTML][HTML] Practice effects of mobile tests of cognition, dexterity, and mobility on patients with multiple sclerosis: data analysis of a smartphone-based observational study

T Woelfle, S Pless, A Wiencierz, L Kappos… - Journal of Medical …, 2021 - jmir.org
Background Smartphones and their built-in sensors allow for measuring functions in disease-
related domains through mobile tests. This could improve disease characterization and …