Allosteric Communication of the Dimerization and the Catalytic Domain in Photoreceptor Guanylate Cyclase

MK Shahu, F Schuhmann, SY Wong, IA Solov'yov… - Biochemistry, 2024 - ACS Publications
Phototransduction in vertebrate photoreceptor cells is controlled by Ca2+-dependent
feedback loops involving the membrane-bound guanylate cyclase GC-E that synthesizes the …

Multilimbed membrane guanylate cyclase signaling system, evolutionary ladder

T Duda, RK Sharma - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
One monumental discovery in the field of cell biology is the establishment of the membrane
guanylate cyclase signal transduction system. Decoding its fundamental, molecular …

Physics-Based Protein Networks Might Recover Effectful Mutations─ a Case Study on Cathepsin G

F Schuhmann, HN Bordallo… - The Journal of Physical …, 2024 - ACS Publications
Molecular dynamics simulations have been remarkably effective for observing and
analyzing structures and dynamics of proteins, with longer trajectories being computed …

Different receptor models show differences in ligand binding strength and location: a computational drug screening for the tick-borne encephalitis virus

F Finke, J Hungerland, IA Solov'yov, F Schuhmann - Molecular Diversity, 2024 - Springer
The tick-borne encephalitis virus (TBE) is a neurotrophic disease that has spread more
rapidly throughout Europe and Asia in the past few years. At the same time, no cure or …